Characterization, comparative, and functional analysis of arylacetamide deacetylase from Gnathostomata organisms

Diaz-Vidal, Tania; Romero-Olivas, Christian Berenice; Martínez-Pérez, Raúl Balam

doi:10.1186/s43141-022-00443-z

Journal of Genetic Engineering and Biotechnology

Table 1 Structural characteristics from AADAC orthologues

From: Characterization, comparative, and functional analysis of arylacetamide deacetylase from Gnathostomata organisms

Organism name	Taxonomy	Prediction method	Identity (%)	Motif			Active site (amino acid no.)			Carboxylesterase family	Transmembrane regions
Organism name	Taxonomy	Prediction method	Identity (%)	HGGG	GXSXG	Superfamily	S	D	H	Carboxylesterase family	Transmembrane regions
Amblyraja radiata	Amphibian	Genome	49.3	HGGG	GDSAG	Alpha/beta hydrolase 3	189	344	374	IV	1
Geotrypetes seraphini	Amphibian	Genome	55.7	HGGG	GDSAG	Alpha/beta hydrolase 3	189	344	373	IV	1
Nanorana parkeri	Amphibian	Genome	57.3	HGGG	GDSAG	Alpha/beta hydrolase 3	189	343	373	IV	0
Rhinatrema bivittatum	Amphibian	Genome	57.8	HGGG	GDSAG	Alpha/beta hydrolase 3	189	343	372	IV	0
Anas platyrhynchos	Birds	Genome	58.8	HGGG	GDSAG	Alpha/beta hydrolase 3	189	343	373	IV	0
Anser cygnoides domesticus	Bird	Genome	59.3	HGGG	GDSAG	Alpha/beta hydrolase 3	189	343	373	IV	0
Antrostomus carolinensis	Bird	Genome	58.3	HGGG	GDSAG	Alpha/beta hydrolase 3	189	343	373	IV	0
Aptenodytes forsteri	Bird	Genome	59.3	HGGG	GDSAG	Alpha/beta hydrolase 3	189	343	373	IV	1
Apteryx australis mantelli	Bird	Genome	64.5	HGGG	GDSAG	Alpha/beta hydrolase 3	189	343	373	IV	1
Apteryx rowi	Bird	Genome	64.5	HGGG	GDSAG	Alpha/beta hydrolase 3	189	343	373	IV	1
Aquila chrysaetos chrysaetos	Bird	Genome	59.8	HGGG	GDSAG	Alpha/beta hydrolase 3	189	343	373	IV	0
Athene cunicularia	Bird	Genome	59.8	HGGG	GDSAG	Alpha/beta hydrolase 3	189	342	373	IV	1
Aythya fuligula	Bird	Genome	59.3	HGGG	GDSAG	Alpha/beta hydrolase 3	189	343	373	IV	0
Balearica regulorum gibbericeps	Bird	Genome	59.3	HGGG	GDSAG	Alpha/beta hydrolase 3	189	343	373	IV	0
Calidris pugnax	Bird	Genome	62.5	HGGG	GDSAG	Alpha/beta hydrolase 3	189	343	373	IV	1
Calypte anna	Bird	Genome	58.3	HGGG	GDSAG	Alpha/beta hydrolase 3	189	343	373	IV	0
Camarhynchus parvulus	Bird	Genome	48	HGGG	GDSAG	Alpha/beta hydrolase 3	189	343	374	IV	0
Catharus ustulatus	Bird	Genome	53.3	HGGG	GDSAG	Alpha/beta hydrolase 3	189	343	373	IV	1
Charadrius vociferus	Bird	Genome	59.6	HGGG	GDSAG	Alpha/beta hydrolase 3	189	343	373	IV	0
Chiroxiphia lanceolata	Bird	Genome	57.6	HGGG	GDSAG	Alpha/beta hydrolase 3	189	343	373	IV	1
Corapipo altera	Bird	Genome	57.1	HGGG	GDSAG	Alpha/beta hydrolase 3	189	343	373	IV	1
Corvus moneduloides	Bird	Genome	54.6	HGGG	GDSAG	Alpha/beta hydrolase 3	189	343	373	IV	0
Coturnix japonica	Bird	Genome	57.3	HGGG	GDSAG	Alpha/beta hydrolase 3	189	343	373	IV	1
Cuculus canorus	Bird	Genome	61	HGGG	GDSAG	Alpha/beta hydrolase 3	189	343	373	IV	1
Cyanistes caeruleus	Bird	Genome	55.3	HGGG	GDSAG	Alpha/beta hydrolase 3	189	343	373	IV	0
Cygnus atratus	Bird	Genome	58.6	HGGG	GDSAG	Alpha/beta hydrolase 3	189	343	373	IV	0
Egretta garzetta	Bird	Genome	60.6	HGGG	GDSAG	Alpha/beta hydrolase 3	190	344	374	IV	2
Empidonax traillii	Bird	Genome	56.1	HGGG	GDSAG	Alpha/beta hydrolase 3	189	343	373	IV	0
Eurypyga helias	Bird	Genome	59.6	HGGG	GDSAG	Alpha/beta hydrolase 3	189	343	373	IV	0
Falco cherrug	Bird	Genome	60	HGGG	GDSAG	Alpha/beta hydrolase 3	189	343	373	IV	1
Falco peregrinus	Bird	Genome	60	HGGG	GDSAG	Alpha/beta hydrolase 3	189	343	373	IV	1
Fulmarus glacialis	Bird	Genome	58.6	HGGG	GDSAG	Alpha/beta hydrolase 3	189	343	373	IV	0
Gallus gallus	Bird	Genome	58.8	HGGG	GDSAG	Alpha/beta hydrolase 3	189	343	373	IV	1
Gavia stellata	Bird	Genome	60	HGGG	GDSAG	Alpha/beta hydrolase 3	189	343	373	IV	0
Haliaeetus albicilla	Bird	Genome	59.3	HGGG	GDSAG	Alpha/beta hydrolase 3	189	343	373	IV	0
Haliaeetus leucocephalus	Bird	Genome	59.3	HGGG	GDSAG	Alpha/beta hydrolase 3	189	343	373	IV	0
Lepidothrix coronata	Bird	Genome	57.3	HGGG	GDSAG	Alpha/beta hydrolase 3	189	343	373	IV	0
Lonchura striata domestica	Bird	Genome	52.4	HGGG	GDSAG	Alpha/beta hydrolase 3	189	343	373	IV	0
Manacus vitellinus	Bird	Genome	54.8	HGGG	GDSAG	Alpha/beta hydrolase 3	189	344	375	IV	0
Meleagris gallopavo	Bird	Genome	56.8	HGGG	GDSAG	Alpha/beta hydrolase 3	189	343	373	IV	1
Melopsittacus undulatus	Bird	Genome	60.8	HGGG	GDSAG	Alpha/beta hydrolase 3	189	343	373	IV	0
Mesitornis unicolor	Bird	Genome	58.6	HGGG	GDSAG	Alpha/beta hydrolase 3	189	343	373	IV	1
Molothrus ater	Bird	Genome	51.4	HGGG	GDSAG	Alpha/beta hydrolase 3	189	343	373	IV	0
Neopelma chrysocephalum	Bird	Genome	55.6	HGGG	GDSAG	Alpha/beta hydrolase 3	189	343	373	IV	0
Nestor notabilis	Bird	Genome	60.8	HGGG	GDSAG	Alpha/beta hydrolase 3	189	343	373	IV	1
Numida meleagris	Bird	Genome	58.8	HGGG	GDSAG	Alpha/beta hydrolase 3	189	343	373	IV	1
Opisthocomus hoazin	Bird	Genome	59.6	HGGG	GDSAG	Alpha/beta hydrolase 3	189	343	373	IV	1
Parus major	Bird	Genome	54.3	HGGG	GDSAG	Alpha/beta hydrolase 3	189	343	373	IV	0
Phalacrocorax carbo	Bird	Genome	60.8	HGGG	GDSAG	Alpha/beta hydrolase 3	189	343	373	IV	1
Phasianus colchicus	Bird	Genome	56.8	HGGG	GDSAG	Alpha/beta hydrolase 3	189	343	373	IV	1
Pipra filicauda	Bird	Genome	56.3	HGGG	GDSAG	Alpha/beta hydrolase 3	189	343	373	IV	1
Pseudopodoces humilis	Bird	Genome	55.3	HGGG	GDSAG	Alpha/beta hydrolase 3	189	343	373	IV	0
Pygoscelis adeliae	Bird	Genome	59.3	HGGG	GDSAG	Alpha/beta hydrolase 3	189	343	373	IV	1
Strigops habroptila	Bird	Genome	60	HGGG	GDSAG	Alpha/beta hydrolase 3	189	343	373	IV	0
Struthio camelus australis	Bird	Genome	63.5	HGGG	GDSAG	Alpha/beta hydrolase 3	189	343	373	IV	1
Taeniopygia guttata	Bird	Genome	52.9	HGGG	GDSAG	Alpha/beta hydrolase 3	189	343	373	IV	0
Tyto alba alba	Bird	Genome	59.6	HGGG	GDSAG	Alpha/beta hydrolase 3	189	343	373	IV	1
Ailuropoda melanoleuca	Mammal	Genome	74.7	HGGG	GDSAG	Alpha/beta hydrolase 3	190	344	374	IV	3
Aotus nancymaae	Mammal	Genome	88.5	HGGG	GDSAG	Alpha/beta hydrolase 3	189	343	373	IV	1
Arvicanthis niloticus	Mammal	Genome	68.9	HGGG	GDSAG	Alpha/beta hydrolase 3	188	342	372	IV	0
Camelus bactrianus	Mammal	Genome	74.4	HGGG	GDSAG	Alpha/beta hydrolase 3	189	343	373	IV	0
Camelus dromedarius	Mammal	Genome	74.4	HGGG	GDSAG	Alpha/beta hydrolase 3	189	343	373	IV	0
Camelus ferus	Mammal	Genome	74.4	HGGG	GDSAG	Alpha/beta hydrolase 3	189	343	373	IV	0
Canis lupus dingo	Mammal	Genome	75.4	HGGG	GDSAG	Alpha/beta hydrolase 3	189	343	373	IV	3
Canis lupus familiaris	Mammal	Genome	75.4	HGGG	GDSAG	Alpha/beta hydrolase 3	189	343	373	IV	3
Castor canadensis	Mammal	Genome	74.4	HGGG	GDSAG	Alpha/beta hydrolase 3	189	343	373	IV	3
Chlorocebus sabaeus	Mammal	Genome	93	HGGG	GDSAG	Alpha/beta hydrolase 3	189	343	373	IV	1
Chrysochloris asiatica	Mammal	Genome	83.2	HGGG	GGSAG	Alpha/beta hydrolase 3	189	343	373	IV	1
Colobus angolensis palliatus - revisar	Mammal	Genome	94	HGGG	GDSAG	Alpha/beta hydrolase 3	189	346	376	IV	1
Condylura cristata	Mammal	Genome	79.8	HGGG	GDSAG	Alpha/beta hydrolase 3	189	344	374	IV	1
Cricetulus griseus	Mammal	Genome	67.7	HGGG	GDSAG	Alpha/beta hydrolase 3	188	342	372	IV	1
Desmodus rotundus	Mammal	Genome	75.9	HGGG	GDSAG	Alpha/beta hydrolase 3	189	343	373	IV	0
Dipodomys ordii	Mammal	Genome	66.4	HGGG	GDSAG	Alpha/beta hydrolase 3	189	343	373	IV	3
Elephantulus edwardii	Mammal	Genome	74.2	HGGG	GDSAG	Alpha/beta hydrolase 3	189	343	373	IV	1
Equus asinus	Mammal	Genome	83.2	HGGG	GDSAG	Alpha/beta hydrolase 3	189	343	373	IV	1
Erinaceus europaeus	Mammal	Genome	75.2	HGGG	GDSAG	Alpha/beta hydrolase 3	189	343	373	IV	0
Galeopterus variegatus	Mammal	Genome	77.9	HGGG	GDSAG	Alpha/beta hydrolase 3	189	343	373	IV	2
Gorilla gorilla gorilla	Mammal	Genome	99	HGGG	GDSAG	Alpha/beta hydrolase 3	189	343	373	IV	1
Grammomys surdaster	Mammal	Genome	68.4	HGGG	GDSAG	Alpha/beta hydrolase 3	188	342	372	IV	1
Halichoerus grypus	Mammal	Genome	76.4	HGGG	GESAG	Alpha/beta hydrolase 3	189	343	373	VII	3
Homo sapiens	Mammal	Validated	100	HGGG	GDSAG	Alpha/beta hydrolase 3	189	343	373	IV	1
Hylobates moloch	Mammal	Genome	96.7	HGGG	GDSAG	Alpha/beta hydrolase 3	189	343	373	IV	1
Leptonychotes weddellii	Mammal	Genome	74.2	HGGG	GESAG	Alpha/beta hydrolase 3	189	343	373	VII	3
Loxodonta africana	Mammal	Genome	82.2	HGGG	GDSAG	Alpha/beta hydrolase 3	189	343	373	IV	1
Macaca mulatta	Mammal	Genome	92.7	HGGG	GDSAG	Alpha/beta hydrolase 3	189	343	373	IV	1
Mandrillus leucophaeus	Mammal	Genome	93.5	HGGG	GDSAG	Alpha/beta hydrolase 3	189	343	373	IV	1
Marmota flaviventris	Mammal	Genome	68.2	HGGG	GDSAG	Alpha/beta hydrolase 3	183	337	366	IV	1
Mastomys coucha	Mammal	Genome	67.4	HGGG	GDSAG	Alpha/beta hydrolase 3	187	342	372	IV	3
Meriones unguiculatus	Mammal	Genome	70.2	HGGG	GDSAG	Alpha/beta hydrolase 3	187	342	372	IV	0
Mesocricetus auratus	Mammal	Genome	66.9	HGGG	GDSAG	Alpha/beta hydrolase 3	188	342	372	IV	3
Microcebus murinus	Mammal	Genome	77.2	HGGG	GDSAG	Alpha/beta hydrolase 3	189	343	373	IV	1
Microtus ochrogaster	Mammal	Genome	67.8	HGGG	GDSAG	Alpha/beta hydrolase 3	190	344	374	IV	0
Miniopterus natalensis	Mammal	Genome	77.4	HGGG	GSSSG	Alpha/beta hydrolase 3	189	343	373	–	1
Mus caroli	Mammal	Genome	68.7	HGGG	GDSAG	Alpha/beta hydrolase 3	188	342	372	IV	1
Mus musculus	Mammal	Validated	69.9	HGGG	GDSAG	Alpha/beta hydrolase 3	188	342	372	IV	0
Mus pahari	Mammal	Genome	69.2	HGGG	GDSSG	Alpha/beta hydrolase 3	188	342	372	–	2
Myotis davidii	Mammal	Genome	74.7	HGGG	GDSAG	Alpha/beta hydrolase 3	189	343	373	IV	3
Myotis lucifugus	Mammal	Genome	75.4	HGGG	GDSAG	Alpha/beta hydrolase 3	189	343	373	IV	2
Myotis myotis	Mammal	Genome	74.9	HGGG	GDSAG	Alpha/beta hydrolase 3	189	343	373	IV	3
Nannospalax galili	Mammal	Genome	72.4	HGGG	GDSAG	Alpha/beta hydrolase 3	189	343	373	IV	0
Nomascus leucogenys	Mammal	Genome	96.7	HGGG	GDSAG	Alpha/beta hydrolase 3	189	343	373	IV	1
Onychomys torridus	Mammal	Genome	68.2	HGGG	GDSAG	Alpha/beta hydrolase 3	189	343	373	IV	1
Ornithorhynchus anatinus	Mammal	Genome	67.2	HGGG	GDSAG	Alpha/beta hydrolase 3	189	343	373	IV	0
Pan paniscus	Mammal	Genome	99.5	HGGG	GDSAG	Alpha/beta hydrolase 3	189	343	373	IV	1
Pan troglodytes	Mammal	Genome	99.2	HGGG	GDSAG	Alpha/beta hydrolase 3	189	343	373	IV	1
Papio anubis	Mammal	Genome	93.7	HGGG	GDSAG	Alpha/beta hydrolase 3	189	343	373	IV	1
Peromyscus leucopus	Mammal	Genome	68.4	HGGG	GDSAG	Alpha/beta hydrolase 3	188	342	372	IV	1
Peromyscus maniculatus bairdii	Mammal	Genome	68.2	HGGG	GDSAG	Alpha/beta hydrolase 3	188	342	372	IV	1
Phoca vitulina	Mammal	Genome	76.2	HGGG	GESAG	Alpha/beta hydrolase 3	189	343	373	VII	3
Piliocolobus tephrosceles	Mammal	Genome	93.7	HGGG	GDSAG	Alpha/beta hydrolase 3	189	343	373	IV	1
Pipistrellus kuhlii	Mammal	Genome	74.4	HGGG	GDSAG	Alpha/beta hydrolase 3	189	343	373	IV	2
Pteropus alecto	Mammal	Genome	69.9	HGGG	GSSSG	Alpha/beta hydrolase 3	189	342	372	–	1
Rattus norvegicus	Mammal	Transcriptome	67.7	HGGG	GDSAG	Alpha/beta hydrolase 3	188	342	372	IV	3
Rattus rattus	Mammal	Genome	67.7	HGGG	GDSAG	Alpha/beta hydrolase 3	188	342	372	IV	3
Rhinopithecus bieti	Mammal	Genome	92.2	HGGG	GDSAG	Alpha/beta hydrolase 3	189	343	372	IV	1
Rhinopithecus roxellana	Mammal	Genome	92.2	HGGG	GDSAG	Alpha/beta hydrolase 3	189	343	373	IV	1
Saimiri boliviensis boliviensis	Mammal	Genome	89.5	HGGG	GDSAG	Alpha/beta hydrolase 3	189	343	373	IV	1
Sapajus apella	Mammal	Genome	89.2	HGGG	GDSAG	Alpha/beta hydrolase 3	189	343	373	IV	1
Talpa occidentalis	Mammal	Genome	82	HGGG	GDSAG	Alpha/beta hydrolase 3	189	343	373	IV	1
Theropithecus gelada	Mammal	Genome	93.5	HGGG	GDSAG	Alpha/beta hydrolase 3	189	343	373	IV	1
Trachypithecus francoisi	Mammal	Genome	92.2	HGGG	GDSAG	Alpha/beta hydrolase 3	189	343	373	IV	1
Urocitellus parryii	Mammal	Genome	69.4	HGGG	GDSAG	Alpha/beta hydrolase 3	183	367	337	IV	3
Vicugna pacos	Mammal	Genome	75.2	HGGG	GDSAG	Alpha/beta hydrolase 3	189	343	373	IV	0
Vulpes vulpes	Mammal	Genome	76.7	HGGG	GDSAG	Alpha/beta hydrolase 3	189	343	373	IV	3
Alligator sinensis	Reptiles	Genome	62.0	HGGG	GDSSG	Alpha/beta hydrolase 3	189	343	373	–	1
Anolis carolinensis	Reptiles	Genome	61.3	HGGG	GDSAG	Alpha/beta hydrolase 3	189	343	373	IV	0
Chelonoidis abingdonii	Reptiles	Genome	63.3	HGGG	GDSAG	Alpha/beta hydrolase 3	189	343	373	IV	0
Crocodylus porosus	Reptiles	Genome	63	HGGG	GDSSG	Alpha/beta hydrolase 3	189	343	373	IV	0
Gavialis gangeticus	Reptiles	Genome	63	HGGG	GDSSG	Alpha/beta hydrolase 3	189	343	373	–	1
Gekko japonicus	Reptiles	Genome	60.1	HGGG	GDSAG	Alpha/beta hydrolase 3	190	344	374	IV	0
Lacerta agilis	Reptiles	Genome	60.5	HGGG	GDSAG	Alpha/beta hydrolase 3	189	343	372	IV	0
Notechis scutatus	Reptiles	Genome	58.1	HGGG	GDSAG	Alpha/beta hydrolase 3	189	343	373	IV	1
Pantherophis guttatus	Reptiles	Genome	58.6	HGGG	GDSAG	Alpha/beta hydrolase 3	189	343	373	IV	0
Pelodiscus sinensis	Reptiles	Genome	60.8	HGGG	GDSAG	Alpha/beta hydrolase 3	199	353	383	IV	0
Podarcis muralis	Reptiles	Genome	62.3	HGGG	GDSAG	Alpha/beta hydrolase 3	189	343	372	IV	0
Pogona vitticeps	Reptiles	Genome	58.8	HGGG	GDSAG	Alpha/beta hydrolase 3	189	343	373	IV	0
Protobothrops mucrosquamatus	Reptiles	Genome	58.1	HGGG	GDSAG	Alpha/beta hydrolase 3	189	343	373	IV	0
Pseudonaja textilis	Reptiles	Genome	58.8	HGGG	GDSAG	Alpha/beta hydrolase 3	189	343	373	IV	0
Python bivittatus	Reptiles	Genome	59.1	HGGG	GDSAG	Alpha/beta hydrolase 3	189	343	373	IV	1
Thamnophis sirtalis	Reptiles	Genome	58.3	HGGG	GDSAG	Alpha/beta hydrolase 3	189	343	373	IV	0
Trachemys scripta elegans	Reptiles	Genome	63.3	HGGG	GDSAG	Alpha/beta hydrolase 3	189	343	373	IV	0
Zootoca vivipara	Reptiles	Genome	61.3	HGGG	GDSAG	Alpha/beta hydrolase 3	189	343	372	IV	0

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