Journal of Genetic Engineering and Biotechnology

Table 3 ADMET properties of the top-two ligands

From: Bioinsecticidal activity of actinomycete secondary metabolites against the acetylcholinesterase of the legume’s insect pest Acyrthosiphon pisum: a computational study

	BBB	Caco2	HIA	P-gp inhibitor	CYP1A2 inhibitor	CYP2C19 inhibitor	CYP2C9 inhibitor	CYP2D6 inhibitor	CYP3A4 inhibitor	Ames mutagenesis	Carcinogenicity	hERG_inhibition	H-HT
Diazepinomicin	No	Yes	Yes	Yes	No	No	No	No	No	No	No	No	Yes
Hygromycin	No	Yes	Yes	No	No	No	No	No	No	Yes	No	No	Yes

BBB blood-brain barrier, HIA human intestinal absorption, Caco2, permeability assay, hERG human Ether-a-go-go-related gene potassium channel, H-HT human hepatotoxicity

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