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Table 7 Multiple linear regression analysis for the association of serum levels of AGEP, VCAM-1, HIF-1α, VEGF, and CTRP3 with the lipid profile

From: Association study of HIF-1α rs11549465 and VEGF rs3025039 genetic variants with diabetic retinopathy in Egyptian patients: crosslinks with angiogenic, inflammatory, and anti-inflammatory markers

Dependent variable

Predictors

R

r2

F

P value*

β

t

P value

VIF

TG

AGEP (μg/ml)

0.47

0.22

16.31

< 0.0001

0.59

5.21

< 0.0001

4.63

 

VCAM-1 (ng/ml)

    

0.14

1.29

0.198

3.98

 

HIF-1α (pg/ml)

    

− 0.08

− 1.05

0.296

2.22

 

VEGF (pg/ml)

    

− 0.12

− 1.66

0.098

1.76

 

CTRP3 (ng/ml)

    

0.18

2.00

0.046

2.84

Cholesterol

AGEP (μg/ml)

0.31

0.10

6.09

< 0.0001

0.26

2.17

0.031

4.63

 

VCAM-1 (ng/ml)

    

0.22

1.91

0.057

3.98

 

HIF-1α (pg/ml)

    

− 0.18

− 2.19

0.030

2.22

 

VEGF (pg/ml)

    

0.06

0.85

0.395

1.76

 

CTRP3 (ng/ml)

    

0.14

1.45

0.149

2.84

HDL-C

AGEP (μg/ml)

0.30

0.09

5.73

< 0.0001

− 0.07

− 0.60

0.551

4.63

 

VCAM-1 (ng/ml)

    

− 0.11

− 0.93

0.353

3.98

 

HIF-1α (pg/ml)

    

− 0.04

− 0.47

0.638

2.22

 

VEGF (pg/ml)

    

0.09

1.15

0.252

1.76

 

CTRP3 (ng/ml)

    

0.17

1.76

0.079

2.84

LDL-C

AGEP (μg/ml)

0.38

0.15

9.58

< 0.0001

0.28

2.32

0.021

4.63

 

VCAM-1 (ng/ml)

    

0.31

2.86

0.005

3.98

 

HIF-1α (pg/ml)

    

− 0.19

− 2.37

0.018

2.22

 

VEGF (pg/ml)

    

− 0.07

− 0.89

0.373

1.76

 

CTRP3 (ng/ml)

    

0.07

0.72

0.471

2.84

VLDL-C

AGEP (μg/ml)

0.477

0.22

16.32

< 0.0001

0.59

5.21

< 0.0001

4.63

 

VCAM-1 (ng/ml)

    

0.14

1.29

0.198

3.98

 

HIF-1α (pg/ml)

    

− 0.08

− 1.05

0.296

2.22

 

VEGF (pg/ml)

    

− 0.12

− 1.66

0.098

1.76

 

CTRP3 (ng/ml)

    

0.18

2.00

0.046

2.84

  1. TG triacylglycerol, HDL-C high-density lipoprotein cholesterol, LDL-C low-density lipoprotein cholesterol, VLDL-C very low-density lipoprotein cholesterol, β standardized coefficient, VIF variance inflation factor, AGEP advanced glycation end products, VCAM-1 vascular cell adhesion molecule-1, HIF- hypoxia-inducible factor-1 alpha, VEGF vascular endothelial growth factor, CTRP3 C1q tumor necrosis factor-related protein 3
  2. *P value obtained from ANOVA table
  3. P < 0.05 was considered significant