Association study of HIF-1α rs11549465 and VEGF rs3025039 genetic variants with diabetic retinopathy in Egyptian patients: crosslinks with angiogenic, inflammatory, and anti-inflammatory markers

Journal of Genetic Engineering and Biotechnology

Table 4 Association of HIF-1α and VEGF variants with diabetic retinopathy risk according to genetic association models using binary logistic regression

	NPDR vs. DWR		PDR vs. DWR
	^#Adjusted OR (95% CI)	P value	^#Adjusted OR (95% CI)	P value
HIF-1α rs11549465 C>T
Homozygous model (TT versus CC)	0.00 (0.00–0.00)	0.968	0.00 (0.00–0.00)	0.999
Heterozygous model (CT versus CC)	0.23 (0.01–4.10)	0.314	14.42 (0.06–3689)	0.346
Dominant model (CC/CT versus CC)	2.15 (0.37–12.49)	0.396	7.87 (0.03–1973)	0.464
Recessive model (TT versus CT/CC)	42.82 (1.72–1007)	0.022	0.51 (0.01–43.92)	0.764
VEGF rs3025039 C>T
Homozygous model (TT versus CC)	0.00 (0.00–0.00)	0.972	0.00 (0.00–0.00)	0.978
Heterozygous model (CT versus CC)	10.88 (0.74–159.86)	0.082	0.01 (65.73)	0.813
Dominant model (CC/CT versus CC)	18.72 (1.42–246.14)	0.026	0.45 (0.003–61.72	0.749
Recessive model (TT versus CT/CC)	7.77 (0.65–93.22)	0.106	3.02 (0.001–6181)	0.776

DWR diabetic without retinopathy, NPDR non-proliferative retinopathy, PDR proliferative retinopathy, OR odds ratio, 95% CI 95% confidence interval
^#Adjusted for age, BMI, FBG, HbA1c, TG, TC, LDL, HDL, and VLDL
P < 0.025 was considered significant after the Bonferroni correction