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Table 3 Genotype distribution and allele frequency of the studied genes in the studied groups

From: Association study of HIF-1α rs11549465 and VEGF rs3025039 genetic variants with diabetic retinopathy in Egyptian patients: crosslinks with angiogenic, inflammatory, and anti-inflammatory markers

  

Control (n = 72)

DWR

(n = 72)

NPDR

(n = 72)

PDR

(n = 72)

HIF-1α rs11549465 C>T

 Genotype distribution, n (%)

CC

47 (65.3)

35 (48.6)

20 (27.8)

25 (34.7)

 

CT

21 (29.2)

27 (37.5)

29 (40.3)

29 (40.3)

 

TT

4 (5.6)

10 (13.9)

23 (31.9)

18 (25)

 

p-HWE

0.344

0.141

0.054

0.062

P value

  

0.079a

< 0.0001a/0.01b

< 0.0001a/0.134b/0.558c

 Allele frequency (%)

C

80.6

67.4

47.9

54.9

 

T

19.4

32.6

52.1

45.1

P value

  

0.011a

< 0.0001a/< 0.0001b

< 0.0001a/0.03b/0.238c

VEGF rs3025039 C>T

 Genotype distribution, n (%)

CC

21 (29.2)

21 (29.2)

17 (23.6)

21 (29.2)

 

CT

30 (41.7)

33 (45.8)

33 (45.8)

29 (40.3)

 

TT

21 (29.2)

18 (25)

22 (30.6)

22 (30.6)

 

p-HWE

0.095

0.410

0.427

0.051

P value

  

0.830a

0.746a/0.663b

0.980a/0.720b/0.712c

 Allele frequency (%)

C

52.8

52.1

45.1

49.3

 

T

47.2

47.9

54.9

50.7

P value

  

0.906a

0.195a/0.238b

0.003a/0.637b/0.479c

  1. Data are expressed as frequencies (percentage)
  2. DWR diabetes without retinopathy, NPDR non-proliferative retinopathy, PDR proliferative diabetic retinopathy, HIF-1α hypoxia-inducible factor-1 alpha, p-HWE p value of Hardy–Weinberg equilibrium, VEGF vascular endothelial growth factor
  3. aSignificance versus control group
  4. bSignificance versus DWR group
  5. cSignificance versus NPDR group
  6. P < 0.05 was considered significant