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Table 3 PLEKHA7 and COL11A1 variants and PACG risk according to genetic association models using binary logistic regression

From: Impact of rs11024102 PLEKHA7, rs3753841 COL11A1 single nucleotide polymorphisms, and serum levels of oxidative stress markers on the risk of primary angle-closure glaucoma in Egyptians

 

PACG vs. control

#Adjusted OR (95% CI)

P value

PLEKHA7 rs11024102 T>C

 Homozygous model (CC versus TT)

7.28 × 108

1

 Heterozygous model (TC versus TT)

0.44 (0.15–1.36)

0.156

 Dominant model (TT/TC versus TT)

0.50 (0.17–1.49)

0.211

 Recessive model (CC versus TC/TT)

7.59 × 108

1

 Major allele (T)

0.60 (0.22–1.64)

0.319

COL11A1 rs3753841 G>A

 Homozygous model (AA versus GG)

1.18 (0.49–6.76)

0.375

 Heterozygous model (GA versus GG)

1.54 (0.51–4.66)

0.45

 Dominant model (GG/GA versus GG)

1.56 (0.55–4.43)

0.401

 Recessive model (AA versus GA/GG)

1.00 (0.37–2.72)

1

 Major allele (G)

1.16 (0.63–2.22)

0.635

  1. PLEKHA7 Pleckstrin homology domain-containing family A member 7, COL11A1 collagen 11 A1, OR odds ratio, 95% CI 95% confidence interval
  2. #Adjusted for sex and age. n= 35 for the control group and 64 for PACG patients
  3. P < 0.025 was considered significant after the Bonferroni correction