Impact of rs11024102 PLEKHA7, rs3753841 COL11A1 single nucleotide polymorphisms, and serum levels of oxidative stress markers on the risk of primary angle-closure glaucoma in Egyptians

Journal of Genetic Engineering and Biotechnology

Table 2 Genotype distribution and allele frequency of the studied genes in control and PACG groups

		Control group (n=35)	PACG group (n=64)	χ² value	P value
PLEKHA7 11024102 T>C
Genotype distribution, n (%)	TT	27 (77.1)	54 (84.4)	1.711	0.425
	TC	8 (22.9)	9 (14.1)
	CC	0 (0)	1 (1.66)
	p-HWE	0.196	0.256
Allele frequency (%)	T	88.6	91.4	0.419	0.517
Allele frequency (%)	C	11.4	8.6
COL11A1 rs3753841 G>A
Genotype distribution, n (%)	GG	9 (25.7)	11 (17.2)	1.023	0.600
	GA	18 (51.4)	37 (57.8)
	AA	8 (22.9)	16 (25)
	p-HWE	0.773	0.103
Allele frequency (%)	G	51.4	46.1	0.516	0.473
Allele frequency (%)	A	48.6	53.9

Data are expressed as frequencies (percentage)
PLEKHA7 Pleckstrin homology domain-containing family A member 7, COL11A1 collagen 11 A1, p-HWE p value of Hardy–Weinberg equilibrium