Fig. 7
From: TRIM21 chimeric protein as a new molecular tool for multispecies IgG detection
The figure depicts the alignment of IgG heavy chain Fc regions from different mammalian species. The residues in gray are conserved among all sequences. The residues marked in bold represent the Mouse IgG Fc hot spots (H433, N434, and H435) necessary for binding to TRIM21 identified in previous studies [6]