Skip to main content

Table 2 Computational pathogenicity prediction scores of BCL-w variants

From: In silico mutational analysis to identify the role and pathogenicity of BCL-w missense variants

S.No

Position

PolyPhen-2

SIFT

Provean

Fathmm

Mutation assessor

1

A159V

0.659

Probably damaging

1.00

Tolerant

− 1.031

Neutral

1.06

1.39

Low

2

G154W

0.938 Probably damaging

0.50

Not Tolerant

− 2.206

Neutral

0.90

1.39

Low

3

R161H

0.993 Probably damaging

1.00

Tolerant

− 1.065

Neutral

0.91

1.1

Low

4

E146K

0.365

Benign

0.94

Tolerant

− 0.118

Neutral

1.06

0.69

Neutral

5

L180Q

1.00

Probably damaging

0.94

Not tolerant

− 2.021

Neutral

0.70

1.67

Low

6

V178M

0.014

Benign

1.00

Not Tolerant

− 0.512

Neutral

0.78

1.5

Low

7

A177P

0.996 Probably damaging

1.00

Tolerant

− 1.640

Neutral

0.90

1.735

Low

8

S169P

0.998 Probably damaging

1.00

Tolerant

− 1.302

Neutral

0.97

1.735

Low

9

A159P

0.973 Probably damaging

1.00

Tolerant

− 1.477

Neutral

0.97

1.39

Low

10

A7T

0.001

Benign

0.38

Tolerant

0.093

Neutral

0.98

− 0.205

Neutral

11

A7G

0.003

Benign

0.38

Tolerant

− 0.272

Neutral

0.95

0.345

Neutral

12

A7V

0.018

Benign

0.38

Tolerant

− 1.56

Neutral

1.04

0

Neutral

13

P8L

0.028

Benign

0.38

Tolerant

− 0.548

Neutral

1.09

0.755

Neutral

14

A15T

0.519 Possibly damaging

0.94

Tolerant

− 0.676

Neutral

1.02

1.78

Low

15

D16H

0.965

Probably damaging

0.94

Not tolerant

− 2.623

Deleterious

0.64

1.905

Low

16

R23K

0.012

Benign

0.88

Tolerant

0.024

Neutral

0.91

0.205

Neutral

17

G34W

0.999

Probably damaging

1.00

Not tolerant

− 2.283

Neutral

0.78

0.825

Low

18

M46T

0.997

Probably damaging

1.00

Not tolerant

− 3.453

Deleterious

0.88

2.215

Medium

19

M46I

0.360

Benign

1.00

Not tolerant

− 0.984

Neutral

1.07

1.87

Low

20

R47Q

0.562

Possibly damaging

1.00

Tolerant

− 2.933

Deleterious

0.76

1.56

Low

21

G50R

1.000

Probably damaging

1.00

Not Tolerant

− 6.246

Deleterious

0.51

2.88

Medium

22

G50V

1.000

Probably damaging

1.00

Not tolerant

− 6.669

Deleterious

0.60

2.185

Medium

23

E54K

1.000

Probably damaging

1.00

Tolerant

− 2.725

Deleterious

0.99

2.855

Medium

24

F57S

0.964

Probably damaging

1.00

Not tolerant

− 5.229

Deleterious

0.97

2.215

Medium

25

R58Q

0.138

Benign

1.00

Tolerant

− 1.238

Neutral

0.93

2.215

Medium

26

R59C

0.001

Benign

1.00

Not tolerant

− 5.428

Deleterious

1.09

0.645

Neutral

27

R59H

0.099

Benign

1.00

Not tolerant

− 2.921

Deleterious

1.12

1.65

Low

28

S62F

0.993

Probably damaging

1.00

Not tolerant

− 4.105

Deleterious

0.86

2.25

Medium

29

A66D

0.001

Benign

1.00

Tolerant

− 1.132

Neutral

1.09

1.055

Low

30

P72T

0.986

Probably damaging

1.00

Not tolerant

− 6.239

Deleterious

0.87

2.805

Medium

31

S74L

0.557

Probably damaging

1.00

Tolerant

− 2.282

Neutral

0.81

1.795

Low

32

Q76K

0.142

Benign

1.00

Tolerant

− 1.504

Neutral

1.00

1.395

Low

33

R78H

0.280

Benign

1.00

Tolerant

− 2.066

Neutral

1.20

2.125

Medium

34

S83F

0.001

Benign

1.00

Not tolerant

− 0.852

Neutral

1.19

1.39

Low

35

D84N

0.073

Benign

1.00

Tolerant

− 1.032

Neutral

1.15

1.48

Low

36

N92Y

1.000

Probably damaging

1.00

Not tolerant

− 7.001

Deleterious

0.43

2.925

Medium

37

R95S

0.994

Probably damaging

1.00

Not tolerant

− 5.221

Deleterious

0.14

2.965

Medium

38

R95H

0.997

Probably damaging

1.00

Not tolerant

− 4.147

Deleterious

0.15

2.275

Medium

39

S110R

1.000

Probably damaging

1.00

Not tolerant

− 3.767

Deleterious

1.18

2.545

Medium

40

V111I

0.254

Benign

1.00

Tolerant

− 0.981

Neutral

0.84

1.795

Low

41

V127M

0.985

Probably damaging

1.00

Not tolerant

− 1.422

Neutral

0.84

1.745

Low

42

A128V

0.000

Benign

1.00

Tolerant

− 0.721

Neutral

0.96

0.435

Neutral

43

E131G

0.034

Benign

1.00

Tolerant

− 2.283

Neutral

1.08

1.645

Low

44

Q133R

0.000

Benign

1.00

Tolerant

Error

1.10

0.11

Neutral

45

A135V

0.067

Benign

1.00

Tolerant

− 1.765

Neutral

1.13

1.5

Low

46

S140C

0.987

Probably damaging

1.00

Not tolerant

− 3.590

Deleterious

0.87

2.16

Medium

47

S141I

0.000

Benign

1.00

Not tolerant

− 3.534

Deleterious

0.95

1.245

Low

48

G142E

0.996

Probably damaging

1.00

Not tolerant

− 6.273

Deleterious

− 1.69

2.875

Medium

49

G152R

0.999

Probably damaging

0.94

Not tolerant

− 3.741

Deleterious

0.85

1.445

Low

50

R160W

1.000

Probably damaging

1.00

Not tolerant

− 3.749

Deleterious

0.91

1.355

Low

51

R161L

0.945

Possibly damaging

1.00

Tolerant

− 2.168

Neutral

1.00

1.1

Low

52

R163W

1.000

Probably damaging

1.00

Not tolerant

− 1.314

Neutral

0.94

0.69

Neutral

53

R171M

0.406

Benign

0.75

Not tolerant

− 1.019

Neutral

0.97

0.69

Neutral

54

V186A

0.972

Probably damaging

0.62

Not tolerant

− 1.041

Neutral

0.03

1.39

Low

55

A188P

0.264

Benign

0.62

Tolerant

− 1.173

Neutral

0.01

1.795

Low