From: In silico mutational analysis to identify the role and pathogenicity of BCL-w missense variants
S.No | Position | PolyPhen-2 | SIFT | Provean | Fathmm | Mutation assessor |
---|---|---|---|---|---|---|
1 | A159V | 0.659 Probably damaging | 1.00 Tolerant | − 1.031 Neutral | 1.06 | 1.39 Low |
2 | G154W | 0.938 Probably damaging | 0.50 Not Tolerant | − 2.206 Neutral | 0.90 | 1.39 Low |
3 | R161H | 0.993 Probably damaging | 1.00 Tolerant | − 1.065 Neutral | 0.91 | 1.1 Low |
4 | E146K | 0.365 Benign | 0.94 Tolerant | − 0.118 Neutral | 1.06 | 0.69 Neutral |
5 | L180Q | 1.00 Probably damaging | 0.94 Not tolerant | − 2.021 Neutral | 0.70 | 1.67 Low |
6 | V178M | 0.014 Benign | 1.00 Not Tolerant | − 0.512 Neutral | 0.78 | 1.5 Low |
7 | A177P | 0.996 Probably damaging | 1.00 Tolerant | − 1.640 Neutral | 0.90 | 1.735 Low |
8 | S169P | 0.998 Probably damaging | 1.00 Tolerant | − 1.302 Neutral | 0.97 | 1.735 Low |
9 | A159P | 0.973 Probably damaging | 1.00 Tolerant | − 1.477 Neutral | 0.97 | 1.39 Low |
10 | A7T | 0.001 Benign | 0.38 Tolerant | 0.093 Neutral | 0.98 | − 0.205 Neutral |
11 | A7G | 0.003 Benign | 0.38 Tolerant | − 0.272 Neutral | 0.95 | 0.345 Neutral |
12 | A7V | 0.018 Benign | 0.38 Tolerant | − 1.56 Neutral | 1.04 | 0 Neutral |
13 | P8L | 0.028 Benign | 0.38 Tolerant | − 0.548 Neutral | 1.09 | 0.755 Neutral |
14 | A15T | 0.519 Possibly damaging | 0.94 Tolerant | − 0.676 Neutral | 1.02 | 1.78 Low |
15 | D16H | 0.965 Probably damaging | 0.94 Not tolerant | − 2.623 Deleterious | 0.64 | 1.905 Low |
16 | R23K | 0.012 Benign | 0.88 Tolerant | 0.024 Neutral | 0.91 | 0.205 Neutral |
17 | G34W | 0.999 Probably damaging | 1.00 Not tolerant | − 2.283 Neutral | 0.78 | 0.825 Low |
18 | M46T | 0.997 Probably damaging | 1.00 Not tolerant | − 3.453 Deleterious | 0.88 | 2.215 Medium |
19 | M46I | 0.360 Benign | 1.00 Not tolerant | − 0.984 Neutral | 1.07 | 1.87 Low |
20 | R47Q | 0.562 Possibly damaging | 1.00 Tolerant | − 2.933 Deleterious | 0.76 | 1.56 Low |
21 | G50R | 1.000 Probably damaging | 1.00 Not Tolerant | − 6.246 Deleterious | 0.51 | 2.88 Medium |
22 | G50V | 1.000 Probably damaging | 1.00 Not tolerant | − 6.669 Deleterious | 0.60 | 2.185 Medium |
23 | E54K | 1.000 Probably damaging | 1.00 Tolerant | − 2.725 Deleterious | 0.99 | 2.855 Medium |
24 | F57S | 0.964 Probably damaging | 1.00 Not tolerant | − 5.229 Deleterious | 0.97 | 2.215 Medium |
25 | R58Q | 0.138 Benign | 1.00 Tolerant | − 1.238 Neutral | 0.93 | 2.215 Medium |
26 | R59C | 0.001 Benign | 1.00 Not tolerant | − 5.428 Deleterious | 1.09 | 0.645 Neutral |
27 | R59H | 0.099 Benign | 1.00 Not tolerant | − 2.921 Deleterious | 1.12 | 1.65 Low |
28 | S62F | 0.993 Probably damaging | 1.00 Not tolerant | − 4.105 Deleterious | 0.86 | 2.25 Medium |
29 | A66D | 0.001 Benign | 1.00 Tolerant | − 1.132 Neutral | 1.09 | 1.055 Low |
30 | P72T | 0.986 Probably damaging | 1.00 Not tolerant | − 6.239 Deleterious | 0.87 | 2.805 Medium |
31 | S74L | 0.557 Probably damaging | 1.00 Tolerant | − 2.282 Neutral | 0.81 | 1.795 Low |
32 | Q76K | 0.142 Benign | 1.00 Tolerant | − 1.504 Neutral | 1.00 | 1.395 Low |
33 | R78H | 0.280 Benign | 1.00 Tolerant | − 2.066 Neutral | 1.20 | 2.125 Medium |
34 | S83F | 0.001 Benign | 1.00 Not tolerant | − 0.852 Neutral | 1.19 | 1.39 Low |
35 | D84N | 0.073 Benign | 1.00 Tolerant | − 1.032 Neutral | 1.15 | 1.48 Low |
36 | N92Y | 1.000 Probably damaging | 1.00 Not tolerant | − 7.001 Deleterious | 0.43 | 2.925 Medium |
37 | R95S | 0.994 Probably damaging | 1.00 Not tolerant | − 5.221 Deleterious | 0.14 | 2.965 Medium |
38 | R95H | 0.997 Probably damaging | 1.00 Not tolerant | − 4.147 Deleterious | 0.15 | 2.275 Medium |
39 | S110R | 1.000 Probably damaging | 1.00 Not tolerant | − 3.767 Deleterious | 1.18 | 2.545 Medium |
40 | V111I | 0.254 Benign | 1.00 Tolerant | − 0.981 Neutral | 0.84 | 1.795 Low |
41 | V127M | 0.985 Probably damaging | 1.00 Not tolerant | − 1.422 Neutral | 0.84 | 1.745 Low |
42 | A128V | 0.000 Benign | 1.00 Tolerant | − 0.721 Neutral | 0.96 | 0.435 Neutral |
43 | E131G | 0.034 Benign | 1.00 Tolerant | − 2.283 Neutral | 1.08 | 1.645 Low |
44 | Q133R | 0.000 Benign | 1.00 Tolerant | Error | 1.10 | 0.11 Neutral |
45 | A135V | 0.067 Benign | 1.00 Tolerant | − 1.765 Neutral | 1.13 | 1.5 Low |
46 | S140C | 0.987 Probably damaging | 1.00 Not tolerant | − 3.590 Deleterious | 0.87 | 2.16 Medium |
47 | S141I | 0.000 Benign | 1.00 Not tolerant | − 3.534 Deleterious | 0.95 | 1.245 Low |
48 | G142E | 0.996 Probably damaging | 1.00 Not tolerant | − 6.273 Deleterious | − 1.69 | 2.875 Medium |
49 | G152R | 0.999 Probably damaging | 0.94 Not tolerant | − 3.741 Deleterious | 0.85 | 1.445 Low |
50 | R160W | 1.000 Probably damaging | 1.00 Not tolerant | − 3.749 Deleterious | 0.91 | 1.355 Low |
51 | R161L | 0.945 Possibly damaging | 1.00 Tolerant | − 2.168 Neutral | 1.00 | 1.1 Low |
52 | R163W | 1.000 Probably damaging | 1.00 Not tolerant | − 1.314 Neutral | 0.94 | 0.69 Neutral |
53 | R171M | 0.406 Benign | 0.75 Not tolerant | − 1.019 Neutral | 0.97 | 0.69 Neutral |
54 | V186A | 0.972 Probably damaging | 0.62 Not tolerant | − 1.041 Neutral | 0.03 | 1.39 Low |
55 | A188P | 0.264 Benign | 0.62 Tolerant | − 1.173 Neutral | 0.01 | 1.795 Low |