Table 2 A summary of SARS-CoV-2 genes coding for proteins that interact with the host DDR
From: The consequences of viral infection on host DNA damage response: a focus on SARS-CoVs
SARS-CoV-2 protein | Function | Host DDR proteins | Protein sequence similarity to SARS-CoV according to [24] | Protein sequence similarity to SARS-CoV according to [23] | |
|---|---|---|---|---|---|
Spike protein (S subunit) | Host cell entry | BRCA1 (in silico) | 87.0% | 91.5% | |
BRCA2 (in silico) | |||||
p53 (in silico) | |||||
BRD4 | |||||
Envelope protein (E protein) | Viral replication and assembly | BRD2/4 | 96.1% | 97.4% | |
ORF8 protein | Modulating the host immune response and interferon signaling inactivation | DNMT1 | 45.3% | ORF8 a | 70.7% |
5-LOX | ORF8 b | 66.7% | |||
ORF9b protein | Suppress antiviral innate immunity | DCTPP1 | 84.7% | NA | |
Nucleocapsid protein (N protein) | Immune suppression | DDX1 | 94.3% | 97.2% | |
ORF10 protein | Inhibits innate immune response | CUL2ZYG11B | NA | ORF9b | 52.4% |
nsp1/leader protein | Suppress cellular protein synthesis and potent inhibitor of host gene expression and antiviral response | Polymerase α | 91.1% | 93.9% | |
nsp5/3C-like proteinase | Processing of viral polyprotein | HDAC2 | 98.7% | 99.7% | |
nsp14 | Guanine N7-methyltransferase 3′–5′ exoribonuclease (evasion of host immune response) | IMPDH2 | 98.7% | 99.1% | |