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Table 1 A summary of SARS-CoV proteins that interact with the host DDR

From: The consequences of viral infection on host DNA damage response: a focus on SARS-CoVs

SARS-CoV protein

Function

Interacting host protein

Assays used to determine the interaction

Protein sequence similarity between SARS-CoV and SARS-CoV-2 according to [24]

Protein sequence similarity between SARS-CoV and SARS-CoV-2 according to [23]

Membrane protein (M protein)

Viral assembly

PDPK1

Co-IP

96.4%

98.2%

nsp3

Viral replication and transcription

RCHY1

Y2H

F3H

MS

86.5%

91.8%

nsp13

Helicase (Viral replication and transcription)

Polymerase δ

Y2H

Pulldown

Co-IP

100.0%

100.0%

nsp14

Guanine N7-methyltransferase and 3′–5′ exoribonuclease activity (viral replication fidelity)

DDX1

Co-IP

98.7%

99.1%