From: The consequences of viral infection on host DNA damage response: a focus on SARS-CoVs
SARS-CoV protein | Function | Interacting host protein | Assays used to determine the interaction | Protein sequence similarity between SARS-CoV and SARS-CoV-2 according to [24] | Protein sequence similarity between SARS-CoV and SARS-CoV-2 according to [23] |
---|---|---|---|---|---|
Membrane protein (M protein) | Viral assembly | PDPK1 | Co-IP | 96.4% | 98.2% |
nsp3 | Viral replication and transcription | RCHY1 | Y2H F3H MS | 86.5% | 91.8% |
nsp13 | Helicase (Viral replication and transcription) | Polymerase δ | Y2H Pulldown Co-IP | 100.0% | 100.0% |
nsp14 | Guanine N7-methyltransferase and 3′–5′ exoribonuclease activity (viral replication fidelity) | DDX1 | Co-IP | 98.7% | 99.1% |