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Table 1 A summary of SARS-CoV proteins that interact with the host DDR

From: The consequences of viral infection on host DNA damage response: a focus on SARS-CoVs

SARS-CoV protein Function Interacting host protein Assays used to determine the interaction Protein sequence similarity between SARS-CoV and SARS-CoV-2 according to [24] Protein sequence similarity between SARS-CoV and SARS-CoV-2 according to [23]
Membrane protein (M protein) Viral assembly PDPK1 Co-IP 96.4% 98.2%
nsp3 Viral replication and transcription RCHY1 Y2H
F3H
MS
86.5% 91.8%
nsp13 Helicase (Viral replication and transcription) Polymerase δ Y2H
Pulldown
Co-IP
100.0% 100.0%
nsp14 Guanine N7-methyltransferase and 3′–5′ exoribonuclease activity (viral replication fidelity) DDX1 Co-IP 98.7% 99.1%