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Fig. 4 | Journal of Genetic Engineering and Biotechnology

Fig. 4

From: The consequences of viral infection on host DNA damage response: a focus on SARS-CoVs

Fig. 4

The potential consequences of viral proteins interaction with host DDR players. Upon infection of the host cells, the viral genome gets translated into proteins. Some of the viral proteins will enter the nucleus and interact with DDR associated players, potentially affecting  the cellular ability to respond to DNA damage and stimulate DNA repair. This can eventually result in accumulation of single-stranded (ss) and double-stranded (ds) breaks in addition to replication fork stalling upon encountering DNA damage. The figure is created with BioRender.com

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