Table 1 Analysis of deleterious missense nsSNPs by various bioinformatics tools
From: Determination of deleterious single-nucleotide polymorphisms of human LYZ C gene: an in silico study
SNP ID | Amino acid change | SIFT (Score) | PolyPhen (Score) | SNAP | PROVEAN | PHD-SNP | SNPs & GO |
|---|---|---|---|---|---|---|---|
rs1800973 | T88N | Deleterious (0.01) | PD (0.997) | Effect | Deleterious | Neutral | Neutral |
rs121913547 | I74T | Deleterious (0.001) | PD (1) | Effect | Deleterious | Disease | Disease |
rs121913549 | F75I | Deleterious (0.001) | PD(0.925) | Effect | Deleterious | Disease | Disease |
rs387906535 | D67H | Deleterious (0.026) | PD (0.979) | Effect | Deleterious | Disease | Disease |
rs387906536 | W82R | Deleterious (0) | PD (1) | Effect | Deleterious | Disease | Disease |
rs121913548 | D85H | Deleterious (0.02) | PD (0.979) | Effect | Deleterious | Disease | Disease |
rs147465274 | R80C | Deleterious (0.046) | PD (0.967) | Effect | Deleterious | Disease | Disease |
rs200491782 | R116S | Deleterious (0.016) | PD (0.994) | Effect | Deleterious | Disease | Neutral |