Table 3 In silico absorption and toxicity profile of the compounds as obtained from the AdmetSar server.
Absorption/toxicity profile | Value | Probability |
|---|---|---|
Human blood-brain barrier (BBB) | − | 0.9570 |
Intestinal absorption (HIA) | + | 0.8161 |
Caco-2 | − | 0.8816 |
Plasma protein binding | 1.096436381 | 1.00 |
AMES Test | − | 0.6600 |
Carcinogenicity | − | 0.9714 |
UGT catalysed | + | 0.6000 |
Acute oral toxicity (LD50; kg/mol) | 2.257 | |
Hepatotoxicity | + | 0.6500 |