Table 3 Antimicrobial activity of Nigrocin-PN and its derivatives against planktonic cells of gram-positive and gram-negative strains, as well as C. albicans
From: A novel antimicrobial peptide found in Pelophylax nigromaculatus
Bacterial strains | Nigrocin-PN (MIC/MBC) (µM) | Nigrocin-M1 (MIC/MBC) (µM) | Nigrocin-M2 (MIC/MBC) (µM) |
|---|---|---|---|
S. aureus (NCTC 10,788) | 4/8 | 4/8 | 512/512 |
S. aureus (ATCC 25,923) | 16/64 | 16/32 | 512/ > 512 |
E. coli (NCTC 10,418) | 8/8 | 8/16 | 128/128 |
C. albicans (NYCY 1467) | 32/128 | 32/128 | > 512/ > 512 |
E. faecalis (NCTC 12,697) | 8/8 | > 512/ > 512 | > 512/ > 512 |
MRSA (NCTC 12,493) | 16/16 | 16/16 | > 512/ > 512 |
MRSA (B038 V1S1A) | 32/64 | 8/32 | > 512/ > 512 |
MRSA (B042 V2E1A) | 32/64 | 16/32 | > 512/ > 512 |
S. constellatus (B003 VISIT) | 8/8 | 4/4 | 256/256 |
K. pneumoniae (ATCC 43,816) | 16/32 | 16/16 | 256/256 |
K. pneumoniae (ATCC 13,883) | 16/64 | 8/32 | 512/ > 512 |
P. aeruginosa (ATCC 27,853) | 64/64 | 512/512 | 512/ > 512 |
P. aeruginosa (ATCC 9097) | 64/128 | 256/512 | 512/ > 512 |
P. aeruginosa (B004 V2S2B) | 16/32 | > 512/ > 512 | > 512/ > 512 |