Sociodemographic and genetic determinants of nonalcoholic fatty liver disease in type 2 diabetes mellitus patients

Adnan, Muhammad; Wajid, Abdul; Noor, Wasif; Batool, Andleeb; Aasim, Muhammad; Abbas, Kamran; Ain, Quratul

doi:10.1186/s43141-022-00349-w

Journal of Genetic Engineering and Biotechnology

Table 5 Multinomial regression analysis for NAFLD in obese T2DM patients under dominant and recessive models (n = 76)

From: Sociodemographic and genetic determinants of nonalcoholic fatty liver disease in type 2 diabetes mellitus patients

		2 × 2 crosstabs			Dominant model				Recessive model
		NAFLD and obese (BMI ≥ 30.0 Kg/m²)	Non-NAFLD and nonobese (BMI < 30.0 Kg/m²)	OR	*AOR*	95.0% Cl for AOR		p-value	*AOR*	95.0% Cl for AOR		p-value
		n (%)	n (%)	OR	*AOR*	Lower	Upper	p-value	*AOR*	Lower	Upper	p-value
Age (years)	≤ 50	20 (46.5)	23 (53.5)	1.180	1.671	0.493	5.668	0.410	1.562	0.464	5.257	0.471
Age (years)	> 50	14 (42.4)	19 (57.6)	1.180	1.671	0.493	5.668	0.410	1.562	0.464	5.257	0.471
Sex	Female	28 (58.3)	20 (41.7)	5.130	3.411	0.997	11.671	0.051	2.831	0.822	9.757	0.099
Sex	Male	06 (21.4)	22 (78.6)	5.130	3.411	0.997	11.671	0.051	2.831	0.822	9.757	0.099
Family income (PKR/month)	≤ 20000	22 (44.9)	27 (55.1)	1.020	0.786	0.255	2.424	0.675	0.653	0.209	2.042	0.464
Family income (PKR/month)	> 20000	12 (44.4)	15 (55.6)	1.020	0.786	0.255	2.424	0.675	0.653	0.209	2.042	0.464
Education	Illiterate	19 (61.3)	12 (38.7)	3.170	2.626	0.818	8.429	0.105	3.323	1.010	10.937	0.048
Education	Literate	15 (33.3)	30 (66.7)	3.170	2.626	0.818	8.429	0.105	3.323	1.010	10.937	0.048
Smoking	Yes	0 (0.0)	02 (100.0)	0.000	3.123 E-008	0.000	.^c	0.998	3.998 E-008	0.000	.^c	0.998
Smoking	No	34 (45.9)	40 (54.1)	0.000	3.123 E-008	0.000	.^c	0.998	3.998 E-008	0.000	.^c	0.998
Any comorbidity	Yes	18 (51.4)	17 (48.6)	1.650	1.567	0.558	4.401	0.394	1.758	0.619	4.990	0.289
Any comorbidity	No	16 (39.0)	25 (61.0)	1.650	1.567	0.558	4.401	0.394	1.758	0.619	4.990	0.289
Family H/o diabetes	Yes	26 (48.1)	28 (51.9)	1.630	1.257	0.375	4.205	0.711	1.482	0.451	4.869	0.517
Family H/o diabetes	No	08 (36.4)	14 (63.6)	1.630	1.257	0.375	4.205	0.711	1.482	0.451	4.869	0.517
Duration of diabetes	> 10 years	08 (53.3)	07 (46.7)	1.540	1.614	0.378	6.885	0.518	1.205	0.276	5.267	0.804
Duration of diabetes	≤ 10 years	26 (42.6)	35 (57.4)	1.540	1.614	0.378	6.885	0.518	1.205	0.276	5.267	0.804
HbA1c (%)	> 8.0	22 (51.2)	21 (48.8)	1.830	2.153	0.758	6.113	0.150	2.061	0.729	5.827	0.173
HbA1c (%)	≤ 8.0	12 (36.4)	21 (63.6)	1.830	2.153	0.758	6.113	0.150	2.061	0.729	5.827	0.173
PNPLA3 genotype	GG + CG	19 (61.3)	12 (38.7)	3.170	3.270	1.131	9.455	0.029
PNPLA3 genotype	CC	15 (33.3)	30 (66.7)	3.170	3.270	1.131	9.455	0.029
PNPLA3 genotype	GG	12 (70.6)	05 (29.4)	4.040					4.534	1.221	16.826	0.024
PNPLA3 genotype	CG + CC	22 (37.3)	37 (62.7)	4.040					4.534	1.221	16.826	0.024

n (%), row percent; NAFLD, nonalcoholic fatty liver disease; T2DM, type 2 diabetes mellitus; BMI, body mass index; OR, odds ratio; AOR, adjusted odds ratio; CI, confidence interval. p-value ≤ 0.05 considered statistically significant

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