Sociodemographic and genetic determinants of nonalcoholic fatty liver disease in type 2 diabetes mellitus patients

Adnan, Muhammad; Wajid, Abdul; Noor, Wasif; Batool, Andleeb; Aasim, Muhammad; Abbas, Kamran; Ain, Quratul

doi:10.1186/s43141-022-00349-w

Journal of Genetic Engineering and Biotechnology

Table 4 Binary logistic regression for NAFLD in obese T2DM patients under dominant and recessive models (n = 129)

From: Sociodemographic and genetic determinants of nonalcoholic fatty liver disease in type 2 diabetes mellitus patients

		2 × 2 crosstabs			Dominant model				Recessive model
		NAFLD and BMI (≥ 30.0 Kg/m²)		OR	*AOR*	95.0% Cl for AOR		p-value	AOR	95.0% Cl for AOR		p-value
		Yes n (%)	No n (%)	OR	*AOR*	Lower	Upper	p-value	AOR	Lower	Upper	p-value
Age (years)	≤ 50	20 (26.3)	56 (73.7)	0.995	1.749	0.496	6.166	0.385	1.923	0.538	6.872	0.314
Age (years)	> 50	14 (26.4)	39 (73.6)	0.995	1.749	0.496	6.166	0.385	1.923	0.538	6.872	0.314
Sex	Female	28 (32.6)	58 (67.4)	2.977	4.010	1.156	13.912	0.029	3.208	0.934	11.015	0.064
Sex	Male	06 (14.0)	37 (86.0)	2.977	4.010	1.156	13.912	0.029	3.208	0.934	11.015	0.064
Family income (PKR/month)	≤ 20000	22 (27.2)	59 (72.8)	1.119	0.807	0.244	2.675	0.726	0.806	0.245	2.647	0.722
Family income (PKR/month)	> 20000	12 (25.0)	36 (75.0)	1.119	0.807	0.244	2.675	0.726	0.806	0.245	2.647	0.722
Education	Illiterate	19 (38.8)	30 (61.2)	2.744	2.936	0.913	9.444	0.071	3.506	1.080	11.375	0.037
Education	Literate	15 (18.8)	65 (81.3)	2.744	2.936	0.913	9.444	0.071	3.506	1.080	11.375	0.037
Smoking	Yes	0 (0.0)	06 (100.0)	0.000	0.000	0.000	.	0.999	0.000	0.000	.	0.999
Smoking	No	34 (27.6)	89 (72.4)	0.000	0.000	0.000	.	0.999	0.000	0.000	.	0.999
Any comorbidity	Yes	18 (29.0)	44 (71.0)	1.304	1.616	0.530	4.924	0.399	1.779	0.572	5.536	0.320
Any comorbidity	No	16 (23.9)	51 (76.1)	1.304	1.616	0.530	4.924	0.399	1.779	0.572	5.536	0.320
Family H/o diabetes	Yes	26 (28.0)	67 (72.0)	1.358	1.798	0.497	6.504	0.371	2.148	0.590	7.820	0.246
Family H/o diabetes	No	08 (22.2)	28 (77.8)	1.358	1.798	0.497	6.504	0.371	2.148	0.590	7.820	0.246
Duration of diabetes	> 10 years	08 (29.6)	19 (70.4)	1.231	1.978	0.472	8.295	0.351	1.481	.341	6.434	0.600
Duration of diabetes	≤ 10 years	26 (25.5)	76 (74.5)	1.231	1.978	0.472	8.295	0.351	1.481	.341	6.434	0.600
HbA1c (%)	> 8.0	22 (29.3)	53 (70.7)	1.453	1.838	0.604	5.592	0.283	1.856	0.607	5.672	0.278
HbA1c (%)	≤ 8.0	12 (22.2)	42 (77.8)	1.453	1.838	0.604	5.592	0.283	1.856	0.607	5.672	0.278
PNPLA3 genotype	GG + CG	19 (39.6)	29 (60.4)	2.883	3.303	1.099	9.920	0.033
PNPLA3 genotype	CC	15 (18.5)	66 (81.5)	2.883	3.303	1.099	9.920	0.033
PNPLA3 genotype	GG	12 (44.4)	15 (55.6)	2.909					4.547	1.123	18.408	0.034
PNPLA3 genotype	CG + CC	22 (21.6)	80 (78.4)	2.909					4.547	1.123	18.408	0.034

n (%), row percent; NAFLD, nonalcoholic fatty liver disease; T2DM, type 2 diabetes mellitus; BMI, body mass index; OR, odds ratio; AOR, adjusted odds ratio; CI, confidence interval. p-value ≤ 0.05 considered statistically significant

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