Molecular docking unveils the potential of andrographolide derivatives against COVID-19: an in silico approach

Journal of Genetic Engineering and Biotechnology

Table 2 Toxicity profile of AGP derivatives

Compounds	LD₅₀ score (mg/kg)	Hepato-toxicity	Carcino-genecity	Immuno toxicity	Muta-genicity	Cyto-toxicity	Toxicity class
1 AGP	1890	Safe	Safe	Toxic	Safe	Mod.Secure	4
2	1050	Safe	Safe	Toxic	Safe	Mod.Secure	4
3	1050	Safe	Safe	Toxic	Safe	Safe	4
4	2000	Safe	Safe	Toxic	Safe	Mod.Secure	4
5	2000	Safe	Safe	Toxic	Safe	Mod.Secure	4
6	2000	Mod.Secure	Mod.Secure	Toxic	Mod.Safe	Mod.Secure	4
7	2000	Safe	Safe	Toxic	Safe	Mod.Secure	4
8	10000	Safe	Safe	Toxic	Mod.Secure	Mod.Secure	6
9	620	Safe	Safe	Toxic	Safe	Safe	4
10	2000	Safe	Mod.Secure	Toxic	Safe	Safe	4
11	2500	Safe	Mod.Secure	Toxic	Safe	Safe	5
12	590	Safe	Mod.Secure	Toxic	Safe	Mod.Secure	4
13	590	Safe	Mod.Secure	Toxic	Safe	Mod.Secure	4
14	590	Mod.Secure	Mod.Safe	Toxic	Mod.Safe	Mod.Secure	4
15	2000	Safe	Mod.Secure	Toxic	Safe	Mod.Secure	4
16	1000	Mod.Secure	Mod.Secure	Safe	Mod.Secure	Mod.Secure	4
17	620	Safe	Safe	Toxic	Safe	Safe	4
REM	1000	Mod.Secure	Mod.Secure	Safe	Mod.Secure	Mod.Secure	4
HCQ	1240	Safe	Mod.Secure	Toxic	Toxic	Safe	4