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Table 4 Effect for the application of T. atroroseus TRP-NRC pigment on Skin irritation score

From: A local Talaromyces atroroseus TRP-NRC isolate: isolation, genetic improvement, and biotechnological approach combined with LC/HRESI-MS characterization, skin safety, and wool fabric dyeing ability of the produced red pigment mixture

Skin irritation scores of pigment (A = erythema formation score; B = oedema formation score)

Time, h

1

24

48

72

Rats

A

B

A

B

A

B

A

B

1

0

0

0

0

0

0

0

0

2

0

0

0

0

0

0

0

0

3

0

0

0

0

1

0

1

0

4

0

0

0

0

0

0

0

0

5

0

0

0

0

0

0

0

0

PII

0/10 = 0

0/10 = 0

0/10 = 0.1

1/10 = 0.1

  1. For erythema: 0 = No erythema, 1 = very slight erythema, 2 = well-defined erythema. For edema: 0 = No edema, 1 = very slight edema. Irritation Index (PII): Negligible 0–0.4, Slight irritation 0.5–1.9, Moderate irritation 2.0–4.9, Severe irritation 5.0–8.0