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Table 4 Effect for the application of T. atroroseus TRP-NRC pigment on Skin irritation score

From: A local Talaromyces atroroseus TRP-NRC isolate: isolation, genetic improvement, and biotechnological approach combined with LC/HRESI-MS characterization, skin safety, and wool fabric dyeing ability of the produced red pigment mixture

Skin irritation scores of pigment (A = erythema formation score; B = oedema formation score)
Time, h 1 24 48 72
Rats A B A B A B A B
1 0 0 0 0 0 0 0 0
2 0 0 0 0 0 0 0 0
3 0 0 0 0 1 0 1 0
4 0 0 0 0 0 0 0 0
5 0 0 0 0 0 0 0 0
PII 0/10 = 0 0/10 = 0 0/10 = 0.1 1/10 = 0.1
  1. For erythema: 0 = No erythema, 1 = very slight erythema, 2 = well-defined erythema. For edema: 0 = No edema, 1 = very slight edema. Irritation Index (PII): Negligible 0–0.4, Slight irritation 0.5–1.9, Moderate irritation 2.0–4.9, Severe irritation 5.0–8.0