Table 3 Transcription factor families binding to MTF1 motif of the promoter regions from prokaryotic database and their roles
TF families | Candidate transcription factors and species | E value | Function |
|---|---|---|---|
AraC family | VqsM, P. aeruginosa | 2.46e-02 | Control the production of virulence factors and quorum-sensing signaling molecules |
AraC family | AmrZ, P. aeruginosa | 3.37e-01 | Associated with biofilms and quorum sensing |
SLC45 (MATP) family | MatP, E. coli | 3.51e-01 | Involved in cross-linking of DNA in the Ter MD and linking the chromosome to the divisome together with ZapA and ZapB |
RR family | CtrA, C. crescentus | 6.12e-01 | Regulate morphogenesis, DNA replication initiation, DNA methylation, cell division, and cell wall metabolism. |
σ-70 factor family | PvdS, P. aeruginosa | 1.70e+00 | Activate transcription of genes for the biosynthesis or the uptake of siderophores. |
TetR family | RutR, E. coli | 1.95e+00 | Regulate genes (rutABCDEFG operon) involved in degradation and synthesis of pyrimidine, degradation of purines, glutamine supply and pH homeostasis. |
LytTR family | AlgR, P. aeruginosa | 3.05e+00 | Control alginate production, type IV pilus function and virulence |
NAP family | EspR, M. tuberculosis | 4.24e+00 | controls the virulence of Mtb by regulating expression of EspA |
Bacterial histone-like proteins | IHF, P. putida | 4.46e+00 | Downregulated genes encoding ribosomal proteins, the alpha subunit of RNA polymerase and components of the ATP synthase. |
AraC family | ArgR, P. aeruginosa | 4.91e+00 | Have major role in the control of certain biosynthetic and catabolic arginine genes |
LexA families | LexA, S. aureus | 6.28e+00 | Govern Salt overly sensitive (SOS) response |
Bacterial histone-like proteins | IHF, P. putida | 7.34e+00 | Essential for xyl gene expression from the TOL plasmid and for the biodegradation of benzyl alcohol |
LuxR protein family | LasR, P. aeruginosa | 7.52e+00 | Involved in transcription, enhances exotoxin A production, plays role in pathogenesis |
LexA families | LexA, C. glutamicum | 8.07e+00 | Represses a number of genes involved in the response to DNA damage |
AraC family | HrpX, X. oryzae | 8.36e+00 | Regulation of virulence and motility required for pilus assembly |