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Journal of Genetic Engineering and Biotechnology

Table 5 ∆∆G of D121A and R133H

From: Variable predicted pathogenic mechanisms for novel MECP2 variants in RTT patients

Variant

∆∆G kcal mol−1a

Unmethylated DNA strand

Methylated DNA strand

Both DNA strands.

Asp121Ala

1.17

0.48

0.40

Arg133His

0.93

1.08

1.26

  1. a Calculated by PREM PDI tool, deleterious threshold point is 1.10 kcal mol−1 corresponding to dataset ROC analysis
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