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Table 5 ∆∆G of D121A and R133H

From: Variable predicted pathogenic mechanisms for novel MECP2 variants in RTT patients

Variant ∆∆G kcal mol−1a
Unmethylated DNA strand Methylated DNA strand Both DNA strands.
Asp121Ala 1.17 0.48 0.40
Arg133His 0.93 1.08 1.26
  1. a Calculated by PREM PDI tool, deleterious threshold point is 1.10 kcal mol−1 corresponding to dataset ROC analysis