Table 3 Physical-chemical properties of wild and mutant amino acids
From: Variable predicted pathogenic mechanisms for novel MECP2 variants in RTT patients
| Â | Â | Charge | Volume | Polarity |
|---|---|---|---|---|
D121A (in MBD) | Wild | Negative | Larger | Polar |
Mutant | Neutral | Smaller | Nonpolar | |
R133H (in MBD) | Wild | Positive | Larger | Basic |
Mutant | Neutral | Smaller | Basic | |
S359Y (in CTD) | Wild | Neutral | Smaller | Polar |
Mutant | Neutral | Larger | Polar | |
P403S (in CTD) | Wild | Neutral | – | Nonpolar |
Mutant | Neutral | – | Polar |