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Table 3 Physical-chemical properties of wild and mutant amino acids

From: Variable predicted pathogenic mechanisms for novel MECP2 variants in RTT patients

   Charge Volume Polarity
D121A (in MBD) Wild Negative Larger Polar
Mutant Neutral Smaller Nonpolar
R133H (in MBD) Wild Positive Larger Basic
Mutant Neutral Smaller Basic
S359Y (in CTD) Wild Neutral Smaller Polar
Mutant Neutral Larger Polar
P403S (in CTD) Wild Neutral Nonpolar
Mutant Neutral Polar