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Table 3 Levels of laboratory parameters in different METAVIR fibrosis stages in patients with hepatitis C virus mono-infection and HCV/Helicobacter pylori (H. pylori) co-infection

From: Prevalence of Helicobacter pylori infection in patients with chronic hepatitis C

Variablesa No fibrosis (F0) Liver fibrosis (F1‑F3) Cirrhosis (F4)
Group Ib (n = 63) Group IIb (n = 32) *P value Group Ib (n = 50) Group IIb (n = 40) *P value Group Ib (n = 18) Group IIb (n = 46) *P value
Age (year) 32.05 ± 0.91 32.50 ± 0.92 0.732 40.58 ± 1.55 46.60 ± 1.66 0.011* 55.89 ± 3.87 53.23 ± 2.50 0.570
ALT (U/L) 19.50 ± 0.90 25.75 ± 1.51 < 0.001* 49.28 ± 2.36 60.05 ± 4.80 0.027* 60.11 ± 5.64 70.91 ± 4.39 0.040*
AST (U/L) 19.42 ± 0.85 29.63 ± 2.11 < 0.001* 49.20 ± 2.94 66.45 ± 6.14 0.010* 65.17 ± 6.66 70.46 ± 5.52 0.046*
T. bilirubin (mg/dl) 0.58 ± 0.03 0.86 ± 0.04 < 0.001* 1.73 ± 0.23 1.84 ± 0.56 0.868 1.72 ± 0.44 1.81 ± 0.19 0.817
Albumin (g/L) 4.25 ± 0.07 3.45 ± 0.08 < 0.001* 3.57 ± 0.30 3.41 ± 0.21 0.666 3.23 ± 0.20 2.89 ± 0.12 0.136
Platelets (109/L) 239.5 ± 7.2 240.7 ± 8.4 0.920 200.2 ± 35.1 143.9 ± 24.5 0.224 245.5 ± 121.5 110.7 ± 13.6 0.025*
AFP (U/L) 1.04 ± 0.08 1.70 ± 0.05 < 0.001* 26.38 ± 3.93 71.04 ± 19.71 0.003* 36.14 ± 4.87 106.96 ± 22.39 0.030*
  1. Variables were expressed as mean ± SEM
  2. aReference values: alanine aminotransferase (ALT) (male up to 41 U/L, female up to 31 U/L); aspartate aminotransferase (AST) (male up to 37 U/L, female up to 31 U/L); total bilirubin (T. bilirubin) up to 1 mg/dL; albumin 3.8‑5.4 g/dL; platelet count 150‑400 ×109/L; alpha fetoprotein (AFP) up to 10 U/L
  3. bGroup I: hepatitis C virus mono-infection; Group II: hepatitis C virus/Helicobacter pylori co-infection
  4. *P < 0.05 is considered significant