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Table 1 Bioactive secondary metabolites from marine sources

From: Promising bioactive compounds from the marine environment and their potential effects on various diseases

  Secondary metabolites from marine sources
SN Secondary metabolites Species Structure Applications Pubchem ID Reference
  Anticancer
1 Aureoverticillactam Streptomyces aureoverticillatus View full size image Cytotoxicity of various cell types of tumors 9868536 [51]
2 Caprolactones Streptomyces sp. Activity against cancer cell lines 10401 [52]
3 Chinikomycins Streptomyces sp. View full size image Antitumor action against different cancer cell lines in humans 11273076 [53]
4 IB-00208 Actinomadura sp. View full size image Cytotoxic activity on tumor cell lines and bactericidal activity against Gram-positive bacteria 139583280 [54]
5 Salinosporamide A (NPI-0052) Salinisporatropica Cytotoxicity, inhibition of the proteosome and inhibition of the activation of NF-κB 11347535 [55]
6 Urdamycin Streptomyces fradiae View full size image Contains biomolecules of aminoglycoside and strong antibacterial and anti-cancer activity 443819 [56]
7 Himastatin Streptomyces hygroscopicus View full size image Includes valine, leucine, threonine, α-hydroxyisovaleric acid, 5-hydroxypiperazic acid, and a dimeric hexahydropyrroloindole. 9855348 [57]
8 Daryamide D Streptomyces strain CNQ-085 Cytotoxic activity against cell line HCT-116 of human colon carcinoma and antifungal activity against Candida albicans 132609319 [58]
9 Marinomycin Marinispora sp. strain CNQ-140 View full size image Inhibition of cancer cell proliferation   [59]
10 Manumycin Streptomyces sp. M045 View full size image Antitumor activity against different human cancer cell lines 6438330 [53]
11 Marmycin Streptomyces sp. View full size image Cytotoxicity of tumor cells tended to correlate with moderate apoptosis induction and arrest during the G1 cell cycle process 91801297 [60]
12 Nonactin Streptomyces tsukubaensis, Streptomyces griseus, Streptomyces chrysomallus, and Streptomyces werraensis. View full size image Vigorous antineoplastic and antibacterial activity 72519 [61]
13 Chartreusin Streptomyces chartreusis Active against certain gram-positive bacteria 5281394 [62]
14 Altemicidin Streptomyces sioyaensis SA-1758. Acaricidal activity and antitumor activity 11036174 [63]
15 Streptochlorin Streptomyces sp. View full size image Promising chemotherapeutic agent to the treatment of cholangiocarcinoma 44608049 [64]
16 Marineosins Streptomyces sp. Significant inhibition of human colon carcinoma 135960042 [65]
17 Ammosamides Streptomyces variabilis Cytotoxicity to the MIA PaCa-2 pancreatic cancer cell line 25113669 [66]
18 Caboxamycin Streptomyces sp. NTK 937 Inhibitory activity against Gram-positive bacteria, selected human tumor cell lines and the enzyme phosphodiesterase 135957253 [67]
19 Hoiamide D Symploca sp View full size image screening inhibitory activity in contrast to 53/Mdm2 interaction 56835050 [68]
20 Niphateolide Niphates olemda p53-Hdm2/Mdm2 interaction inhibitor 132989992 [69]
21 Hexylitaconic acid Arthrinium sp blocks p53/Mdm2 binding 11447214 [70]
22 Lissoclinidine B Lissoclinum cf. badium kills altered cells with wild-type p53 25147779 [71]
23 Himeic acid A Aspergillus sp. Ubiquitin-Activating Enzyme (E1) inhibitory action 11774903 [72]
24 Girolline Cymbastela cantharell and Axinella brevistyla initiating G2/M cell cycle arrest in cancer cells 362388 [73]
25 Leucettamol A Leucetta aff. microrhaphis View full size image inhibits the ubiquitin E2 enzymes Ubc13 and Uev1A by 50% 6271251 [74]
26 Dysidiolide Dysidea etheria capable of inhibiting Cdc25 protein phosphatase 11269661 [75]
27 Sulfircin Ircinia sp inhibit Cdc25 phosphatase 44381469 [76]
28 Coscinosulfate Coscinoderma mathewsi inhibitory activity towards Cdc25A 102305354 [77]
29 Halenaquinone Xestospongia carbonaria irreversible inhibitor of recombinant human Cdc25B phosphates 370346 [78]
30 Secalonic acid D Penicillium oxalicum View full size image slow the course of the cell cycle in human embryonic palatal mesenchymal cells 73431 [79]
31 Stellettin B Jaspis stellifera decrease in Cdk and an increase in p27 expression 5352082 [80]
  Antibacterial
32 Abyssomicins Verrucosispora sp. Inhibits the pathway between chorismate and para-aminobenzoic acid 12094197 [81]
33 Frigocyclinone Streptomyces griseus Lead molecule against Kaposi’s Sarcoma Associated Herpesvirus
KSHV
11476774 [82]
34 Gutingimycin Streptomyces sp. View full size image Antibacterial antifungal and antimicroalgal activities 136835719 [83]
35 Helquinoline Janibacterlimosus Antibacterial antifungal and antimicroalgal activities 10466080 [84]
36 Himalomycins Streptomyces sp. Antimicrobial activity against Gram-positive bacteria 11765992 [85]
37 Lajollamycin Streptomyces nodosus View full size image Antimicrobial activity against drug-sensitive and -resistant Gram-positive bacteria and inhibited the growth of B16-F10 tumor cells in vitro 139587457 [32]
38 Tylosin Streptomyces fradiae View full size image Potential for the treatment of respiratory and other infections caused by Mycoplasma species   [86]
39 Maklamicin Micromonospora sp. GMKU326 Antimicrobial activity against Gram-positive bacteria 101796870 [87]
40 Lobophorin K Streptomyces sp. M-207 View full size image Antibiotic activity against pathogenic Gram-positive bacteria 139590476 [88]
41 Asenjonamide C Streptomyces asenjonii strain KNN 42 Antimicrobial activity against Gram-positive bacteria 139589509 [20]
42 Gilvocarcin HE Streptomyces sp. View full size image More significant cytotoxicity and antimicrobial activity due to the vinyl side chain 102439806 [21]
43 Zunyimycins Streptomyces sp. FJS31-2 View full size image Inhibits the proliferation of lung cancer cells by the activation of apoptosis by an AKT pathway   [22]
44 Formicamycins A Streptomyces formicae View full size image Potent antibacterial activity against clinical MRSA and VRE isolates   [23]
45 Allocyclinones Actinoallomurus View full size image Possess activity against various Gram-positive bacteria, including antibiotic-resistant strains, with increasing antibacterial potency with the number of chlorine substitutes   [24]
46 Ageloline A Streptomyces sp. SBT345 Able to reduce oxidative stress and genomic damage induced by the oxidative stress inducer 4-nitroquinoline-1-oxide (NQO) 1884 [26]
47 Buanmycin Streptomyces sp View full size image Inhibition of sortase A, which is a promising target for antibiotic Discovery   [89]
48 Citreamicin Streptomyces caelestis View full size image Citreamicins exhibit cytotoxic activity against HeLa and Hep62 cells in addition to their potent antibiotic activity 3083114 [28]
49 Kocurin Kocuria sp. strain MI-67-EC3-038 View full size image Kocurin is active against methicillin-resistant Staphylococcus aureus (MRSA)   [29]
50 Fijimycins Streptomyces sp. View full size image Possess significant in vitro antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA) strains   [86]
51 Arylomycin Streptomyces sp. HCCB10043 View full size image Inhibits a promising antimicrobial target, type I signal peptidase (SPase)   [90]
  Antibacterial; anticancer
  1-Hydroxy-1-Norresistomycin Streptomyces variabilis Potent cytotoxic activity against cell lines viz. HMO2 (gastric adenocarcinoma) and HePG2 (hepatic carcinoma) in vitro   [91]
  Antibacterial; antifungal
52 Bonactin Streptomyces sp. View full size image Bonactin displayed antimicrobial activity against both Gram-positive and Gram-negative bacteria as well as antifungal activity 11741721  
  Anti-inflammatory
53 Diazepinomicin (ECO-4601) Micromonosproa sp. Preclinical broad-spectrum antitumor potential, antioxidant and anti-protease activities. 9868980 [92]
54 Cyclomarins Streptomyces sp. View full size image Interesting lead structures for the development of drugs against tuberculosis and malaria   [93]
  Neurogenic activity
55 Komodoquinone A Streptomyces sp. KS3 Induces differentiation of neuronal cells in the neuroblastoma cell line, Neuro 2A and arrests the cell cycle in step G1 11756746 [94]
56 Granaticins Streptomyces lateritius View full size image Granaticinhas significant antitumor activity against P-388 lymphocytic leukemia in mice and cytotoxicity against KB cells.   [95]
57 Hymenialdisine Agelasidae, Axinellidae, and Halichondriidae suppresses many pro inflammatory cytokines (IL-1, IL-2, IL-6, and NO) by inhibition of NF-kB signaling pathway 135413546 [96]
  Antifungal
58 Amphotericin B Streptomyces nodosus View full size image Treatment of most systemic fungal infections 91819969  
  Anti tuberculosis
59 Rifampicin - View full size image Rifampicin had immunomodulatory effects through its ability to modify human monocyte production of measured cytokines   [97]
60 Streptomycin - View full size image Antibiotic activity against gram-positive and gram- negative bacteria 19649 [97]
61 Amikacin - View full size image Potent activity against Antibiotic-Resistant Clinical Isolates 37768 [97]
62 Viomycin - View full size image Tuberculostatic agent active against both streptomycin – sensitive nad streptomycin – resistant strains 135565959 [97]
63 Capreomycin - View full size image Bactericidal in vitro among the anti-TB drugs against non-replicating tubercle bacilli 135565060 [97]
64 Kanamycin - View full size image Kanamycin intramuscular administration had a satisfactory effect in mice with staphylococci, pneumococci, and Ulebsiella pneumonia infections 6032 [97]
65 Cycloserine - View full size image Antituberculous activity invitro and invivo 6234 [97]