Promising bioactive compounds from the marine environment and their potential effects on various diseases

Karthikeyan, Akash; Joseph, Abey; Nair, Baiju G.

doi:10.1186/s43141-021-00290-4

Journal of Genetic Engineering and Biotechnology

Table 1 Bioactive secondary metabolites from marine sources

From: Promising bioactive compounds from the marine environment and their potential effects on various diseases

	Secondary metabolites from marine sources
SN	Secondary metabolites	Species	Structure	Applications	Pubchem ID	Reference
	Anticancer
1	Aureoverticillactam	Streptomyces aureoverticillatus		Cytotoxicity of various cell types of tumors	9868536	[51]
2	Caprolactones	Streptomyces sp.		Activity against cancer cell lines	10401	[52]
3	Chinikomycins	Streptomyces sp.		Antitumor action against different cancer cell lines in humans	11273076	[53]
4	IB-00208	Actinomadura sp.		Cytotoxic activity on tumor cell lines and bactericidal activity against Gram-positive bacteria	139583280	[54]
5	Salinosporamide A (NPI-0052)	Salinisporatropica		Cytotoxicity, inhibition of the proteosome and inhibition of the activation of NF-κB	11347535	[55]
6	Urdamycin	Streptomyces fradiae		Contains biomolecules of aminoglycoside and strong antibacterial and anti-cancer activity	443819	[56]
7	Himastatin	Streptomyces hygroscopicus		Includes valine, leucine, threonine, α-hydroxyisovaleric acid, 5-hydroxypiperazic acid, and a dimeric hexahydropyrroloindole.	9855348	[57]
8	Daryamide D	Streptomyces strain CNQ-085		Cytotoxic activity against cell line HCT-116 of human colon carcinoma and antifungal activity against Candida albicans	132609319	[58]
9	Marinomycin	Marinispora sp. strain CNQ-140		Inhibition of cancer cell proliferation		[59]
10	Manumycin	Streptomyces sp. M045		Antitumor activity against different human cancer cell lines	6438330	[53]
11	Marmycin	Streptomyces sp.		Cytotoxicity of tumor cells tended to correlate with moderate apoptosis induction and arrest during the G1 cell cycle process	91801297	[60]
12	Nonactin	Streptomyces tsukubaensis, Streptomyces griseus, Streptomyces chrysomallus, and Streptomyces werraensis.		Vigorous antineoplastic and antibacterial activity	72519	[61]
13	Chartreusin	Streptomyces chartreusis		Active against certain gram-positive bacteria	5281394	[62]
14	Altemicidin	Streptomyces sioyaensis SA-1758.		Acaricidal activity and antitumor activity	11036174	[63]
15	Streptochlorin	Streptomyces sp.		Promising chemotherapeutic agent to the treatment of cholangiocarcinoma	44608049	[64]
16	Marineosins	Streptomyces sp.		Significant inhibition of human colon carcinoma	135960042	[65]
17	Ammosamides	Streptomyces variabilis		Cytotoxicity to the MIA PaCa-2 pancreatic cancer cell line	25113669	[66]
18	Caboxamycin	Streptomyces sp. NTK 937		Inhibitory activity against Gram-positive bacteria, selected human tumor cell lines and the enzyme phosphodiesterase	135957253	[67]
19	Hoiamide D	Symploca sp		screening inhibitory activity in contrast to 53/Mdm2 interaction	56835050	[68]
20	Niphateolide	Niphates olemda		p53-Hdm2/Mdm2 interaction inhibitor	132989992	[69]
21	Hexylitaconic acid	Arthrinium sp		blocks p53/Mdm2 binding	11447214	[70]
22	Lissoclinidine B	Lissoclinum cf. badium		kills altered cells with wild-type p53	25147779	[71]
23	Himeic acid A	Aspergillus sp.		Ubiquitin-Activating Enzyme (E1) inhibitory action	11774903	[72]
24	Girolline	Cymbastela cantharell and Axinella brevistyla		initiating G2/M cell cycle arrest in cancer cells	362388	[73]
25	Leucettamol A	Leucetta aff. microrhaphis		inhibits the ubiquitin E2 enzymes Ubc13 and Uev1A by 50%	6271251	[74]
26	Dysidiolide	Dysidea etheria		capable of inhibiting Cdc25 protein phosphatase	11269661	[75]
27	Sulfircin	Ircinia sp		inhibit Cdc25 phosphatase	44381469	[76]
28	Coscinosulfate	Coscinoderma mathewsi		inhibitory activity towards Cdc25A	102305354	[77]
29	Halenaquinone	Xestospongia carbonaria		irreversible inhibitor of recombinant human Cdc25B phosphates	370346	[78]
30	Secalonic acid D	Penicillium oxalicum		slow the course of the cell cycle in human embryonic palatal mesenchymal cells	73431	[79]
31	Stellettin B	Jaspis stellifera		decrease in Cdk and an increase in p27 expression	5352082	[80]
	Antibacterial
32	Abyssomicins	Verrucosispora sp.		Inhibits the pathway between chorismate and para-aminobenzoic acid	12094197	[81]
33	Frigocyclinone	Streptomyces griseus		Lead molecule against Kaposi’s Sarcoma Associated Herpesvirus KSHV	11476774	[82]
34	Gutingimycin	Streptomyces sp.		Antibacterial antifungal and antimicroalgal activities	136835719	[83]
35	Helquinoline	Janibacterlimosus		Antibacterial antifungal and antimicroalgal activities	10466080	[84]
36	Himalomycins	Streptomyces sp.		Antimicrobial activity against Gram-positive bacteria	11765992	[85]
37	Lajollamycin	Streptomyces nodosus		Antimicrobial activity against drug-sensitive and -resistant Gram-positive bacteria and inhibited the growth of B16-F10 tumor cells in vitro	139587457	[32]
38	Tylosin	Streptomyces fradiae		Potential for the treatment of respiratory and other infections caused by Mycoplasma species		[86]
39	Maklamicin	Micromonospora sp. GMKU326		Antimicrobial activity against Gram-positive bacteria	101796870	[87]
40	Lobophorin K	Streptomyces sp. M-207		Antibiotic activity against pathogenic Gram-positive bacteria	139590476	[88]
41	Asenjonamide C	Streptomyces asenjonii strain KNN 42		Antimicrobial activity against Gram-positive bacteria	139589509	[20]
42	Gilvocarcin HE	Streptomyces sp.		More significant cytotoxicity and antimicrobial activity due to the vinyl side chain	102439806	[21]
43	Zunyimycins	Streptomyces sp. FJS31-2		Inhibits the proliferation of lung cancer cells by the activation of apoptosis by an AKT pathway		[22]
44	Formicamycins A	Streptomyces formicae		Potent antibacterial activity against clinical MRSA and VRE isolates		[23]
45	Allocyclinones	Actinoallomurus		Possess activity against various Gram-positive bacteria, including antibiotic-resistant strains, with increasing antibacterial potency with the number of chlorine substitutes		[24]
46	Ageloline A	Streptomyces sp. SBT345		Able to reduce oxidative stress and genomic damage induced by the oxidative stress inducer 4-nitroquinoline-1-oxide (NQO)	1884	[26]
47	Buanmycin	Streptomyces sp		Inhibition of sortase A, which is a promising target for antibiotic Discovery		[89]
48	Citreamicin	Streptomyces caelestis		Citreamicins exhibit cytotoxic activity against HeLa and Hep62 cells in addition to their potent antibiotic activity	3083114	[28]
49	Kocurin	Kocuria sp. strain MI-67-EC3-038		Kocurin is active against methicillin-resistant Staphylococcus aureus (MRSA)		[29]
50	Fijimycins	Streptomyces sp.		Possess significant in vitro antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA) strains		[86]
51	Arylomycin	Streptomyces sp. HCCB10043		Inhibits a promising antimicrobial target, type I signal peptidase (SPase)		[90]
	Antibacterial; anticancer
	1-Hydroxy-1-Norresistomycin	Streptomyces variabilis		Potent cytotoxic activity against cell lines viz. HMO2 (gastric adenocarcinoma) and HePG2 (hepatic carcinoma) in vitro		[91]
	Antibacterial; antifungal
52	Bonactin	Streptomyces sp.		Bonactin displayed antimicrobial activity against both Gram-positive and Gram-negative bacteria as well as antifungal activity	11741721
	Anti-inflammatory
53	Diazepinomicin (ECO-4601)	Micromonosproa sp.		Preclinical broad-spectrum antitumor potential, antioxidant and anti-protease activities.	9868980	[92]
54	Cyclomarins	Streptomyces sp.		Interesting lead structures for the development of drugs against tuberculosis and malaria		[93]
	Neurogenic activity
55	Komodoquinone A	Streptomyces sp. KS3		Induces differentiation of neuronal cells in the neuroblastoma cell line, Neuro 2A and arrests the cell cycle in step G1	11756746	[94]
56	Granaticins	Streptomyces lateritius		Granaticinhas significant antitumor activity against P-388 lymphocytic leukemia in mice and cytotoxicity against KB cells.		[95]
57	Hymenialdisine	Agelasidae, Axinellidae, and Halichondriidae		suppresses many pro inflammatory cytokines (IL-1, IL-2, IL-6, and NO) by inhibition of NF-kB signaling pathway	135413546	[96]
	Antifungal
58	Amphotericin B	Streptomyces nodosus		Treatment of most systemic fungal infections	91819969
	Anti tuberculosis
59	Rifampicin	-		Rifampicin had immunomodulatory effects through its ability to modify human monocyte production of measured cytokines		[97]
60	Streptomycin	-		Antibiotic activity against gram-positive and gram- negative bacteria	19649	[97]
61	Amikacin	-		Potent activity against Antibiotic-Resistant Clinical Isolates	37768	[97]
62	Viomycin	-		Tuberculostatic agent active against both streptomycin – sensitive nad streptomycin – resistant strains	135565959	[97]
63	Capreomycin	-		Bactericidal in vitro among the anti-TB drugs against non-replicating tubercle bacilli	135565060	[97]
64	Kanamycin	-		Kanamycin intramuscular administration had a satisfactory effect in mice with staphylococci, pneumococci, and Ulebsiella pneumonia infections	6032	[97]
65	Cycloserine	-		Antituberculous activity invitro and invivo	6234	[97]

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