Missense variants in the TNFA epitopes and their effects on interaction with therapeutic antibodies—in silico analysis

Journal of Genetic Engineering and Biotechnology

Table 7 Predicted pathogenicity of the selected variants

Variants	SIFT_Class	Polyphen_Class	PMut	Meta-SNP	PredictSNP1.0
TNFA^G66C	Deleterious	Probably damaging	Disease	Disease	Deleterious
TNFA^G66S	Deleterious	Possibly damaging	Disease	Disease	Deleterious
TNFA^R131Q	Tolerated	Benign	Neutral	Neutral	Neutral
TNFA^E135G	Deleterious	Possibly damaging	Disease	Disease	Deleterious
TNFA^R138Q	Tolerated	Benign	Neutral	Neutral	Neutral
TNFA^R138W	Tolerated	Possibly damaging	Neutral	Neutral	Deleterious
TNFA^Y141S	Deleterious	Benign	Disease	Neutral	Deleterious