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Table 7 Predicted pathogenicity of the selected variants

From: Missense variants in the TNFA epitopes and their effects on interaction with therapeutic antibodies—in silico analysis

Variants SIFT_Class Polyphen_Class PMut Meta-SNP PredictSNP1.0
TNFAG66C Deleterious Probably damaging Disease Disease Deleterious
TNFAG66S Deleterious Possibly damaging Disease Disease Deleterious
TNFAR131Q Tolerated Benign Neutral Neutral Neutral
TNFAE135G Deleterious Possibly damaging Disease Disease Deleterious
TNFAR138Q Tolerated Benign Neutral Neutral Neutral
TNFAR138W Tolerated Possibly damaging Neutral Neutral Deleterious
TNFAY141S Deleterious Benign Disease Neutral Deleterious