SNP_ID | Amino acid positiona | Amino acid change | ∆∆G (Kcal/mol)b | Antibody chains | MutaBindb | PPcheck | ||
---|---|---|---|---|---|---|---|---|
mCSM-PPI2 | SAAMBE-3D | MutaBind | ∆∆G (kcal/mol) | Total stabilizing energy (kJ/mol) | ||||
WT | – | – | – | – | – | H | – | − 290.62 |
– | – | – | – | – | L | – | − 55.79 | |
rs140654183 | 105 | T/N | 0.463 | 0.67 | 0.84 | H | 0.58 | − 294.29 |
– | – | – | – | – | L | 0.98 | − 56.15 | |
rs760036765 | 111 | A/T | − 0.711 | 0.54 | 1.35 | H | 1.62 | − 300.47 |
– | – | – | – | – | L | 1.01 | − 55.71 | |
rs770509340 | 138 | R/Q | 0.075 | 1.47 | 0.49 | H | 0.25 | − 284.33 |
– | – | – | – | – | L | 0.96 | − 54.37 | |
rs141307820 | 138 | R/W | 0.668 | 1.03 | 0.72 | H | 0.44 | − 285.08 |
– | – | – | – | – | L | 1.23 | − 55.81 | |
rs370893734 | 140 | D/N | 1.279 | 0.96 | 2.4 | H | 0.75 | − 293.72 |
– | – | – | – | – | L | 1.41 | − 62.05 | |
rs370893734 | 140 | D/Y | 0.213 | 0.78 | 4 | H | 1.01 | − 285.94 |
– | – | – | – | – | L | 1.42 | − 53.07 | |
rs763621932 | 141 | Y/S | 2.219 | 1.34 | 2.45 | H | 2.07 | − 270.91 |
– | – | – | – | – | L | 1.43 | − 55.23 |