SNP_ID
|
Amino acid positiona
|
Amino acid change
|
∆∆G (Kcal/mol)b
|
Antibody chains
|
MutaBindb
|
PPcheck
|
---|
mCSM-PPI2
|
SAAMBE-3D
|
MutaBind
|
∆∆G (kcal/mol)
|
Total stabilizing energy (kJ/mol)
|
---|
WT
|
–
|
–
|
–
|
–
|
–
|
H
|
–
|
− 269.69
|
–
|
–
|
–
|
–
|
–
|
L
|
–
|
− 152.18
|
rs1298153213
|
45
|
D>N
|
− 0.619
|
0.95
|
0.61
|
H
|
0.98
|
− 277.93
|
–
|
–
|
–
|
–
|
–
|
L
|
0.46
|
− 152.11
|
rs373646181
|
85
|
V>F
|
− 1.58
|
0.01
|
0.7
|
H
|
0.97
|
− 271.68
|
–
|
–
|
–
|
–
|
–
|
L
|
0.54
|
− 152.18
|
rs778731236
|
85
|
V>G
|
0.416
|
1.55
|
0.99
|
H
|
1.08
|
− 266.54
|
–
|
–
|
–
|
–
|
–
|
L
|
0.47
|
− 152.18
|
rs373646181
|
85
|
V>I
|
0.339
|
0.53
|
0.79
|
H
|
1.01
|
− 274.09
|
–
|
–
|
–
|
–
|
–
|
L
|
0.48
|
− 152.17
|
rs376368223
|
131
|
R>Q
|
− 0.078
|
0.94
|
2.31
|
H
|
2.52
|
− 236.86
|
–
|
–
|
–
|
–
|
–
|
L
|
0.57
|
− 152.06
|
rs777545571
|
135
|
E>G
|
0.784
|
0.67
|
2.25
|
H
|
1.03
|
− 269.49
|
–
|
–
|
–
|
–
|
–
|
L
|
1.98
|
− 145.12
|
rs758189183
|
135
|
E>K
|
1.119
|
0.67
|
1.86
|
H
|
0.92
|
− 279.21
|
–
|
–
|
–
|
–
|
–
|
L
|
1.74
|
− 157.25
|
rs770509340
|
138
|
R>Q
|
0.026
|
2.25
|
1.77
|
H
|
0.41
|
− 269.36
|
–
|
–
|
–
|
–
|
–
|
L
|
1.96
|
− 120.82
|
rs141307820
|
138
|
R>W
|
0.652
|
1.53
|
2.19
|
H
|
0.51
|
− 269.49
|
–
|
–
|
–
|
–
|
–
|
L
|
2.42
|
− 142.18
|
rs370893734
|
140
|
D>N
|
0.64
|
0.75
|
0.64
|
H
|
0.42
|
− 269.56
|
–
|
–
|
–
|
–
|
–
|
L
|
0.88
|
− 147.77
|
rs370893734
|
140
|
D>Y
|
− 0.122
|
0.25
|
0.92
|
H
|
0.74
|
− 269.58
|
–
|
–
|
–
|
–
|
–
|
L
|
1.21
|
− 149.7
|
- aAmino acid positions were calculated excluding the signal peptide (76 amino acids)
- bPositive values of ∆∆G indicate decreasing affinity