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Journal of Genetic Engineering and Biotechnology
Fig. 6 | Journal of Genetic Engineering and Biotechnology

Fig. 6

From: Missense variants in the TNFA epitopes and their effects on interaction with therapeutic antibodies—in silico analysis

Fig. 6

Interactions of TNFA with golimumab and infliximab. Interactions between TNFA and the heavy chain of golimumab in the wild-type (A) and TNFAY141S variant (B) structures. Interactions between TNFA and the light chain of infliximab in the wild-type (C) and TNFAR138W variant (D) structures. Forest green- antibody heavy chain; hot pink- antibody light chain; deep teal- TNFA; yellow- interface; red- mutated residue

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