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Journal of Genetic Engineering and Biotechnology
Fig. 5 | Journal of Genetic Engineering and Biotechnology

Fig. 5

From: Missense variants in the TNFA epitopes and their effects on interaction with therapeutic antibodies—in silico analysis

Fig. 5

Interactions of TNFA with golimumab and infliximab. 2D plots of interactions between TNFA and the heavy chain of golimumab in the wild-type (A) and TNFAY141S variant (B) structures. 2D plots of interactions between TNFA and the light chain of infliximab in the wild-type (C) and TNFAR138W variant (D) structures. TNFA residues are shown along the horizontal axis and antibody residues are delineated along the vertical axis. Green- hydrogen bonds; cyan- salt bridges/ionic interactions; and red- cation-pi interactions

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