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Journal of Genetic Engineering and Biotechnology
Fig. 3 | Journal of Genetic Engineering and Biotechnology

Fig. 3

From: Missense variants in the TNFA epitopes and their effects on interaction with therapeutic antibodies—in silico analysis

Fig. 3

Interactions between TNFA and certolizumab pegol. 2D plots of interactions between TNFA and the heavy chain of certolizumab pegol in the wild-type (A) and TNFAR131Q variant (B) structures. 2D plots of interactions between TNFA and the light chain of certolizumab pegol in the wild-type (C), TNFAE135G (D), TNFAR138Q (E), and TNFAR138W (F) variant structures. TNFA residues are shown along the horizontal axis and certolizumab pegol residues are delineated along the vertical axis. Green- hydrogen bonds; cyan- salt bridges/ionic interactions; and red- cation-pi interactions

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