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Journal of Genetic Engineering and Biotechnology
Fig. 1 | Journal of Genetic Engineering and Biotechnology

Fig. 1

From: Missense variants in the TNFA epitopes and their effects on interaction with therapeutic antibodies—in silico analysis

Fig. 1

Interactions between TNFA and adalimumab. 2D plots of interactions between the light chain of adalimumab and TNFAWT (A), TNFAG66C (B), and TNFAG66S (C) structures. Distance between TNFAGlu-23 and ADAAsp-1 in the L chain in wild-type (D), TNFAG66C, (E) and TNFAG66S (F) variant structures. In the 2D interaction plots TNFA residues are shown along the horizontal axis and adalimumab light chain residues are delineated along the vertical axis. Grey- contacts/interactions (within 4 Å)

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