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Table 3 TCF7L2 genotyping and allele frequencies for GDM cases and controls

From: Are single nucleotide polymorphisms rs7903146 and rs12255372 in transcription factor 7-like 2 gene associated with an increased risk for gestational diabetes mellitus in Egyptian women?

  GDM N = 114 (%) Controls N = 114 (%) P value; OR (95th CI)
rs7903146 (C/T)
 CC 18 (15.2%) 41 (35%) Ref
 CT 53 (46.5%) 62 (54%) 0.04; 1.9 (1.0 to 3.78)
 TT 43 (37.7%) 11 (9.6%) <0.001; 8.9 (3.7–21.1)
 CT+TT vs. CC 96 (84.2%) 73 (64%) <0.001; 3 (1.5–5.6)
 TT vs. CC +CT 43 (47.7%) 11 (9.6%) <0.001; 5.6 (2.7–11.7)
 HWE 0.8 0.07  
rs7903146 (C/T)
 C 39% 63.1% Ref
 T 61% 36.8% <0.001; 2.6 (1.8–3.9)
rs12255372 (G/T)
 GG 31 (27.2%) 60 (52.6%) Ref
 GT 55 (48.2 %) 45 (39.5%) 0.004; 2.3 (1.3–4.2 )
 TT 28 (24.6%) 9 (7.9%) <0.001; 6 (2.5–14.3)
 GT+TT vs. GG 83 (72.8%) 54 (47.7%) <0.001; 2.9 (1.7–5.1)
 TT vs. GG +GT 28 (24.6%) 9 (9.7%) 0.001; 3.7 (1.7–8.4 )
 HWE 0.7 0.8  
rs12255372 (G/T)
 G 48.7% 24.3% Ref
 T 51.3% 75.5% <0.001; 2.9 (1.9–4.4 )
  1. OR odds ratio, CI confidence interval, HWE Hardy–Weinberg equation
  2. P<0.05 is considered significant