Table 3 TCF7L2 genotyping and allele frequencies for GDM cases and controls
GDM N = 114 (%) | Controls N = 114 (%) | P value; OR (95th CI) | |
|---|---|---|---|
rs7903146 (C/T) | |||
CC | 18 (15.2%) | 41 (35%) | Ref |
CT | 53 (46.5%) | 62 (54%) | 0.04; 1.9 (1.0 to 3.78) |
TT | 43 (37.7%) | 11 (9.6%) | <0.001; 8.9 (3.7–21.1) |
CT+TT vs. CC | 96 (84.2%) | 73 (64%) | <0.001; 3 (1.5–5.6) |
TT vs. CC +CT | 43 (47.7%) | 11 (9.6%) | <0.001; 5.6 (2.7–11.7) |
HWE | 0.8 | 0.07 | |
rs7903146 (C/T) | |||
C | 39% | 63.1% | Ref |
T | 61% | 36.8% | <0.001; 2.6 (1.8–3.9) |
rs12255372 (G/T) | |||
GG | 31 (27.2%) | 60 (52.6%) | Ref |
GT | 55 (48.2 %) | 45 (39.5%) | 0.004; 2.3 (1.3–4.2 ) |
TT | 28 (24.6%) | 9 (7.9%) | <0.001; 6 (2.5–14.3) |
GT+TT vs. GG | 83 (72.8%) | 54 (47.7%) | <0.001; 2.9 (1.7–5.1) |
TT vs. GG +GT | 28 (24.6%) | 9 (9.7%) | 0.001; 3.7 (1.7–8.4 ) |
HWE | 0.7 | 0.8 | |
rs12255372 (G/T) | |||
G | 48.7% | 24.3% | Ref |
T | 51.3% | 75.5% | <0.001; 2.9 (1.9–4.4 ) |