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Table 2 Diagnostic power of single and combined candidate markers (CRP, cholesterol, BMI, ALT, and miRNA34) to diagnose NAFLD

From: NAFLD mark: an accurate model based on microRNA-34 for diagnosis of non-alcoholic fatty liver disease patients

Variables AUC (95% CI) p value Cut-off Sensitivity Specificity PPV NPV
miRNA-34 0.72 (0.66–0.77) < 0.0001 3.5 70 64 81 49
ALT 0.73 (0.67–0.79) < 0.0001 32 77 66 83 57
BMI 0.81 (0.76–0.86) < 0.0001 25 75 67 83 56
Cholesterol 0.85 (0.79–0.90) < 0.0001 160 83 83 92 67
CRP 0.88 (0.84–0.92) < 0.0001 3 85 85 92 72
CRP+ cholesterol 0.93 (0.89–0.96) < 0.0001 1.6 90 85 93 79
CRP+ cholesterol+ BMI 0.94 (0.91–0.97) < 0.0001 1.4 91 87 95 78
CRP+ cholesterol+ BMI+ALT 0.95 (0.93–0.97) < 0.0001 1.4 92 88 95 81
CRP+ cholesterol+ BMI+ALT+ miRNA-34 0.98 (0.93–0.99) < 0.0001 1.5 93 90 95 86