Table 1 Patient’s characteristics before and after antiviral treatments
Treatment with sofosbuvir and ribavirin | ||||||
Variables | *IL-28B CC genotype | P value | *IL-28B T allele carriers | P value | ||
Before | After | Before | After | |||
Without zinc administration | ||||||
ALT (U/L) | 48·4 ± 10·3 | 42·50 ± 11·6 | 0·184 | 62·5 ± 15·4 | 49·1 ± 13·3 | 0·164 |
AST (U/L) | 46·6 ± 10·1 | 37·3 ± 9·1 | 0·010 | 75·2 ± 16·4 | 57·2 ± 13·3 | 0·088 |
Bilirubin (mg/dL) | 1·0 ± 0·2 | 0·9 ± 0·15 | 0·885 | 1·1 ± 0·2 | 0·93 ± 0·12 | 0·363 |
Albumin (g/dL) | 3·6 ± 0·98 | 4·3 ± 1·1 | 0·027 | 3·4 ± 0·88 | 3·7 ± 1·1 | 0·349 |
WBCs (× 109/L) | 4·6 ± 1·2 | 4·7 ± 0·7 | 0·961 | 4·7 ± 0·9 | 5·1 ± 1·3 | 0·465 |
Platelet count (×109/L) | 185·2 ± 30·1 | 157·5 ± 29·9 | 0·461 | 157·8 ± 20·3 | 160·0 ± 23·1 | 0·946 |
With zinc administration | ||||||
ALT (U/L) | 41·8 ± 10·9 | 36·8 ± 9·8 | 0·060 | 38·0 ± 10·2 | 34·3 ± 9·7 | 0·382 |
AST (U/L) | 42·5 ± 9·3 | 35·4 ± 9·2 | 0·004 | 38·3 ± 10·1 | 35·3 ± 10·2 | 0·361 |
Bilirubin (mg/dL) | 1·1 ± 0·21 | 0·6 ± 0·15 | 0·0001 | 1·2 ± 0·2 | 0·8 ± 0·1 | 0·013 |
Albumin (g/dL) | 3·5 ± 0·99 | 4·2 ± 0·98 | 0·049 | 3·6 ± 0·9 | 3·9 ± 1·1 | 0·041 |
WBCs (×109/L) | 4·7 ± 1·5 | 5·8 ± 1·5 | 0·111 | 4·6 ± 1·3 | 5·9 ± 1·3 | 0·004 |
Platelet count (×109/L) | 164·8 ± 25·7 | 153·8 ± 27·7 | 0·647 | 149·7 ± 26·6 | 152·0 ± 30·9 | 0·908 |
Treatment with sofosbuvir, ribavirin, and pegylated interferon | ||||||
Variables | *IL-28B CC genotype | P value | *IL-28B T allele carriers | P value | ||
Before | After | Before | After | |||
Without zinc administration | ||||||
ALT (U/L) | 41·0 ± 12·5 | 35·3 ± 9·5 | 0·461 | 44·3 ± 11·4 | 42·2 ± 11·1 | 0·530 |
AST (U/L) | 43·3 ± 12·1 | 32·7 ± 8·95 | 0·032 | 44·9 ± 12·8 | 37·4 ± 11·3 | 0·008 |
Bilirubin (mg/dL) | 1·5 ± 0·2 | 1·0 ± 0·2 | 0·033 | 1·0 ± 0·17 | 0·7 ± 0·6 | 0·884 |
Albumin (g/dL) | 3·4 ± 0·8 | 3·9 ± 0·8 | 0·084 | 4·1 ± 1·1 | 4·3 ± 1·2 | 0·664 |
WBCs (×109/L) | 5·1 ± 1·4 | 4·5 ± 0·96 | 0·497 | 5·8 ± 1·3 | 3·74 ± 0·9 | 0·004 |
Platelet count (×109/L) | 150·8 ± 31·2 | 166·0 ± 33·6 | 0·647 | 201·5 ± 33·3 | 164·1 ± 29·5 | 0·908 |
With zinc administration | ||||||
ALT (U/L) | 49·8 ± 10·9 | 36·8 ± 9·4 | 0·011 | 47·2 ± 11·5 | 33·2 ± 9·6 | 0·024 |
AST (U/L) | 50·4 ± 12·2 | 34·4 ± 11·4 | 0·017 | 63·5 ± 16·1 | 40·7 ± 11·6 | 0·009 |
Bilirubin (mg/dL) | 1·4 ± 0·09 | 0·75 ± 0·03 | 0·036 | 1·30 ± 0·6 | 0·70 ± 0·2 | 0·337 |
Albumin (g/dL) | 3·2 ± 0·9 | 4·2 ± 1·1 | 0·002 | 3·2 ± 0·82 | 4·3 ± 1·1 | 0·004 |
WBCs (×109/L) | 6·2 ± 1·1 | 4·9 ± 1·0 | 0·061 | 6·9 ± 1·5 | 4·5 ± 1·1 | 0·0008 |
Platelet count (×109/L) | 200·3 ± 32·9 | 197·4 ± 25·4 | 0·890 | 213·5 ± 34·9 | 173·3 ± 24·4 | 0·030 |