Fig. 2

Schematic illustration of GABA shunt. Transamination of α-ketoglutarate by GABA-α ketoglutarate transaminase (GABA-T) to produce glutamate which is decarboxylated to GABA by glutamic acid decarboxylase (GAD). GABA-T metabolizes GABA to succinic semialdehyde which is oxidized to succinate by succinic semialdehyde dehydrogenase (SSADH). Then, succinate can enter the Krebs cycle and complete the loop