Table 3 Significantly enriched BioGRID interactions of most commonly mutated genes indicating the molecular function, biological process, cellular component, and biological pathways
Description | Term ID | Corrected P value |
|---|---|---|
Biological process | ||
Covalent chromatin modification | GO:0016569 | 8.13797E−05 |
Chromatin organization | GO:0006325 | 0.001237802 |
Bone marrow development | GO:0048539 | 0.002607555 |
Histone modification | GO:0016570 | 0.006671044 |
Chromosome organization | GO:0051276 | 0.009673322 |
Molecular function | ||
Histone kinase activity (H3-Y41 specific) | GO:0035401 | 0.049878314 |
Histone tyrosine kinase activity | GO:0035400 | 0.049878314 |
Cellular component | ||
Euchromatin | GO:0000791 | 0.009699567 |
U11/U12 snRNP | GO:0034693 | 0.049903619 |
Biological pathways (reactome) | ||
Epigenetic regulation of gene expression | REAC:R-HSA-212165 | 0.010116540 |
Amine ligand-binding receptors | REAC:R-HSA-375280 | 0.008152302 |
Human protein atlas | ||
Lymph node; non-germinal center cells [high] | HPA:0310443 | 0.033971887 |
Human phenotype ontology | ||
Abnormal cellular immune system morphology | HP:0010987 | 0.002011691 |
Abnormal leukocyte morphology | HP:0001881 | 0.002011691 |
Chest pain | HP:0100749 | 0.00232273 |
Abnormal platelet morphology | HP:0011875 | 0.002471705 |
Abnormal immune system morphology | HP:0032251 | 0.00256098 |
Abdominal pain | HP:0002027 | 0.002830113 |
Arterial thrombosis | HP:0004420 | 0.003992637 |
Weight loss | HP:0001824 | 0.00406694 |
Abnormal number of granulocyte precursors | HP:0012137 | 0.004170906 |
Megaloblastic erythroid hyperplasia | HP:0200143 | 0.004170906 |