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Table 1 Lipinski rule of 5: Determination of drug likeliness of andrographolide

From: Andrographolide binds to spike glycoprotein and RNA-dependent RNA polymerase (NSP12) of SARS-CoV-2 by in silico approach: a probable molecule in the development of anti-coronaviral drug

S No Parameters Prerequisite Andrographolide Result
1 Molecular mass Less than 500 Dalton 350 Dalton Pass
2 High lipophilicity (expressed as LogP) Less than 5 1.9626 Pass
3 Hydrogen bond donors Less than 5 3 Pass
4 Hydrogen bond acceptors Less than 10 5 Pass
5 Molar refractivity Between 40 and 130 93.560364 Pass