Table 2 The details of significant gene networks of diseases which were constructed by hypoxia-associated genes

Brain damages

Parkinson disease

104

14

9

CYCS, BID, GPX1, OGDH, TYR, SOD2, SLC18A2, XDH, NQO1

*

Mitochondrial damage

117

8

7

HIF1A, NOS1, NOS2, SLC9A1, SLC8A1, SOD2, PARP1

**

Alzheimer disease

93

16

9

CYCS, BAG1, SLC8B1, MICU1, MCU, DNM1, OPA1, DNM1L, CASP3

*

Drug toxicity (Dexamethasone)

Diabetes

48

21

15

SGK1, NR3C1, EP300, RUNX2, SOST, DKK1, LRP6, LRP5, DVL1, GSK3B, IRS1, IRS2, PDPK1, AKT1, TBC1D4

*

Neurotoxicity

45

17

17

SGK1, NR3C1, EP300, RUNX2, SOST, DKK1, LRP6, LRP5, DVL1, GSK3B, IRS1, IRS2, MAPT, PDPK1, AKT1, SIRT2, TBC1D4

**

Bone resorption

141

20

16

SGK1, NR3C1, EP300, RUNX2, SOST, DKK1, LRP6, LRP5, DVL1, AKT1, TGFBR1, CTNNB1, BGLAP, TNSFS11, CSF1, TNFRSF11B

**

Carcinogenesis

Ovarian cancer

698

9

8

VEGFC, LRP1B, ATR, RIF1, HDAC10, UIMC1, BARD1, LRPPRC

**

Colorectal cancer

1067

11

9

VEGFC, ATR, LRP1B, CA4, CD109, AKAP12, MKI67, DOT1L, CENPF

**

Breast cancer

1660

21

18

VEGFC, ATR, LRP1B, LRP6, GPNMB, APOB, GAS8, CCDC170, ATAD2, POLQ, SLX4, USP1, SYNE2, BARD1, BMX, UIMC1, CENPF,USP1

**

Metastasis

5278

7

6

ATAD2, BMX, BDKRB2, PRKDC, SYTL2, CD200

**

Cardiomyopathy

330

7

6

XIRP1, ALPK3, BDKRB2, SYNE2, LRPPRC, APOB,

**

Raynaud disease

36

5

3

DDAH1, ARG2, RHOA

*