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Journal of Genetic Engineering and Biotechnology
Fig. 9 | Journal of Genetic Engineering and Biotechnology

Fig. 9

From: Gene network analysis to determine the effect of hypoxia-associated genes on brain damages and tumorigenesis using an avian model

Fig. 9

Gene network construction of hypoxia-associated genes for the description of the ovarian cancer (OC). Results show that VEGF (vascular endothelial growth factor), considered as the protein ligand, is involved in ovarian carcinoma. VEGF enhances cancer cell mobility and promotes the cancer cell metastasis. LRP1B gene encodes low-density lipoprotein receptor-related protein 1B, which plays several important roles in the normal cell function and development due to their interactions with multiple ligands. The disruption of LRP1B is based on several types of cancers and could be considered as the tumor suppressor. Deletion or downregulation of LRP1B is associated with the chemotherapy resistance in OC

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