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Journal of Genetic Engineering and Biotechnology
Fig. 7 | Journal of Genetic Engineering and Biotechnology

Fig. 7

From: Gene network analysis to determine the effect of hypoxia-associated genes on brain damages and tumorigenesis using an avian model

Fig. 7

The association between drug toxicity of dexamethasone and bone resorption in low oxygen conditions. Bone resorption is known as another side effect of dexamethasone. According to our findings, the RUNX2 (Runt-related transcription factor 2) gene is associated with the skeletal morphogenesis by activating the tumor necrosis factor receptor superfamily (TNFRSF) that inhibits the osteoclast differentiation. Additionally, RUNX2 transcription factor induces tumor necrosis factor superfamily (TNFSF) ligand and bone resorption. TNF/TNFR proteins are classified as the cytokine, and it is also demonstrated that cytokines might contribute in bone resorptions directly by increasing proliferation and activity of cells in the osteoclast lineage. TNFRSF11A gene encodes osteoprotegerin (OPG) protein, which is also known as osteoclastogenesis inhibitory factor (OCIF)

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