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Fig. 6 | Journal of Genetic Engineering and Biotechnology

Fig. 6

From: Gene network analysis to determine the effect of hypoxia-associated genes on brain damages and tumorigenesis using an avian model

Fig. 6

The development of neurotoxicity process in hypoxia condition by drug toxicity of Dexamethasone. Neurotoxicity occurs when neurotoxins affect the normal activity of the nervous system and ultimately, damage the nervous tissue. In the other words, all biological processes that lead to the development of the nervous system are inhibited. Generally, the function of the nervous system depends on neurite (axons and dendrites) outgrowth. In neurotoxicity, the number and length of neurites and axonogenes are decreased. MAPT provides microtubule-associated protein tau found in the nervous system and contributes in the process of stabilizing microtubules and structures the cytoskeleton. Figure 6 suggests that dexamethasone inhibits MAPT gene and decreases the growth of neurons in the nervous system and leads to neurotoxicity

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