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Journal of Genetic Engineering and Biotechnology
Fig. 5 | Journal of Genetic Engineering and Biotechnology

Fig. 5

From: Gene network analysis to determine the effect of hypoxia-associated genes on brain damages and tumorigenesis using an avian model

Fig. 5

The role of dexamethasone in the process of inducing diabetes in hypoxia condition. This figure illustrates that the NR3C1 gene activates SGK1 (Serine/threonine-protein kinase) and other TFs block two receptors (LRP6 and LRP5) in the cell membrane. In fact, SGK1 gene is well known as the regulator for many biological pathways such as TFs, receptors, and transporters. Thus, WNT-FZD (Wingless/Int1-Frizzled) and LRP6 activate protein kinase GSK38. We found that it has a positive effect on the SLC2A4 gene, indirectly. It is proved that the SLC2A4 gene encodes the glucose transporters family (GLUTs) in diabetes, which is considered as an insulin-sensitive transporter. GLUTs contribute in glucose hemostasis and diabetes diseases

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