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Journal of Genetic Engineering and Biotechnology
Fig. 13 | Journal of Genetic Engineering and Biotechnology

Fig. 13

From: Gene network analysis to determine the effect of hypoxia-associated genes on brain damages and tumorigenesis using an avian model

Fig. 13

The candidate genes involved in cardiomyopathy and their regulation roles in the low oxygen concentration. Cardiomyopathy is related to the abnormal formation of muscle heart and leads to the hypertrophic muscle. Heart muscle cells are sensitive to the low oxygen concentration that results in the death of cardiac myocytes. Results of this study showed that MKI67 induces cardiomyopathy, and BDKRB2 inhibits the disorder. MKI67 gene encodes the nuclear protein, which is related to cellular proliferation and might also play a role in the chromatin organization; however, it is poorly understood. The regulatory roles of other enriched genes in cardiomyopathy networks (including SYNE2, APOB, XIRP1, ALPK3, and LRPPRC) are not clear

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