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Journal of Genetic Engineering and Biotechnology
Fig. 12 | Journal of Genetic Engineering and Biotechnology

Fig. 12

From: Gene network analysis to determine the effect of hypoxia-associated genes on brain damages and tumorigenesis using an avian model

Fig. 12

Identification of regulatory roles of candidate genes in metastasis under hypoxia condition. We found that PRKDC, CD200, SYTL2, and BDKRB2 enhanced the metastasis event. PRKDC encodes DNA-PKcs protein that participates in the development of the immune system and is usually overexpressed in cancer metastasis. SYTL2 (synaptotagmin like 2) is one of the members of C2 domain-containing protein family. It is demonstrated that SYTL2 contributes in ovarian cancer and its overexpressed one can promote the metastatic potential in ovarian cancer. Immunoglobulin superfamily (IgSF) contains two domains including CD200 and CD200-R, and their interaction is also involved in functions of myeloid cells. The overexpression of CD200 in breast cancer can be considered as an important risk factor for metastasis. Bradykinin contains nine amino acid peptide chains and is implicated in many responses including vasodilation, edema, smooth muscle spasm, and pain fiber stimulation

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