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Table 3 Effect of Crateva adansonii leaf extracts and its Lupeol containing LF on hot plate assay in mice

From: Analgesic and anti-inflammatory potential of Lupeol isolated from Indian traditional medicinal plant Crateva adansonii screened through in vivo and in silico approaches

Groups Drug treatment Pain threshold (in s)
30 min 60 min 90 min 120 min
I Control 0.1%CMC 4.02 ± 0.02 5.33 ± 0.14 5.77 ± 0.09 5.65 ± 0.12
II Pentazocine 10 mg/kg 9.66 ± 0.11** 10.35 ± 0.92*** 11.63 ± 0.60*** 10.76 ± 0.06***
III ME 200 mg/kg 5.08 ± 0.22 6.09 ± 0.55 6.23 ± 0.24 5.96 ± 0.40
IV ME 400 mg/kg 6.66 ± 0.12 8.47 ± 0.22* 7.30 ± 0.45* 7.28 ± 0.40*
V CE 200 mg/kg 6.31 ± 0.09 8.06 ± 0.07* 8.76 ± 0.22* 8.54 ± 0.05*
VI CE 400 mg/kg 7.45 ± 0.54* 9.60 ± 0.22** 9.10 ± 0.43** 10.22 ± 0.32***
VII LF 100mg/kg 8.40 ± 0.15** 10.06 ± 0.88*** 11.45 ± 0.22*** 11.60 ± 0.96***
  1. The data are presented as mean ± SEM n = 6. *p < 0.05, **p < 0.01, and ***p < 0.001 vs. control. Data were analyzed by using one-way ANOVA followed by Dunnett’s “t” test using the software Graph Pad
  2. ME Methanolic extract of C. adansonii leaf, CE Chloroform extract of C. adansonii leaf, LF Lupeol fraction