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Table 3 Overall sensitivity, specificity, PPV, NPV, and accuracy of investigated methylated genes and tumor markers

From: Alterations of PTEN and SMAD4 methylation in diagnosis of breast cancer: implications of methyl II PCR assay

Variables

Sen.%

Spe. %

PNV%

NPV%

Acc.%

Early detection of breast cancer vs. all non-cancer

 CEA (ng/ml)

70

40

65.1

45.5

58.5

 CA15.3 (ng/ml)

75

48

69.8

54.5

64.6

 PTEN

100

94

96.4

100

97.7

 SMAD4

100

100

100

100

100

Early stage breast cancer vs. all non-cancer

 CEA (ng/ml)

51.1

51.4

57.5

45

51.3

 CA15.3 (ng/ml)

51.1

51.4

57.5

45

51.3

 PTEN

84.4

51.4

69.1

72

70

 SMAD4

66.7

40

58.8

48.3

55

Low-grade breast cancer vs. all non-cancer

 CEA (ng/ml)

66

60

73

51.4

66

 CA15.3 (ng/ml)

54

50

54

50

54

 PTEN

80

70

80

70

80

 SMAD4

60

60

60

60

60