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Table 1 Demographic and clinicopathological data of breast carcinoma patients

From: Alterations of PTEN and SMAD4 methylation in diagnosis of breast cancer: implications of methyl II PCR assay

Parameter

Breast cancer

Benign

Healthy

P value

Number

80

30

20

–

Age (years, mean ± SD)

52.4 ± 9.1

52.0 ± 9.3

51.5 ± 8.9

0.923a

Menopause, number (percentage)

 Post-menopausal

35 (43.8%)

13 (43.3%)

8 (40%)

0.955b

 Pre-menopausal

45 (56.2%)

17 (56.7%)

12 (60%)

Tumor invasion number (percentage)

 In situ

32(40%)

–

–

–

 Invasive

48(60%)

–

–

–

Tumor depth (stage)

 Early (T ≤ 2)

35(43.8%)

–

–

–

 Late (T > 2)

45 (56.2%)

–

–

–

Tumor grade

 Low (G1)

30(37.5%)

–

–

–

 High (G2–3)

50 (62.5%)

–

–

–

Lymph node invasion

 Negative

42 (52.5%)

–

–

–

 Positive

38 (47.5%)

–

–

–

Estrogen receptor (ER)

 Negative

40 (50%)

–

–

–

 Positive

40 (50%)

–

–

–

Progesterone receptor (PgR)

 Negative

28 (35%)

–

–

–

 Positive

52 (65%)

–

–

–

HER-2/neu status

 Negative

28 (35%)

–

–

–

 Positive

52 (65%)

–

–

–

  1. *Statistical analysis was carried out by (a) ANOVA test and (b) chi-squared (χ2) test in case of dichotomized values
  2. P > 0.05 is considered non-significant; P ≤ 0.05 is considered significant