Table 4 Interaction between wild-type and mutant SARS-CoV-2 papain-like viral protease with ISG-15
From: Novel mutations in NSP-1 and PLPro of SARS-CoV-2 NIB-1 genome mount for effective therapeutics
Receptor | TongDock_A score | Cluster size | Binding affinity score (kcal/mol) | Dissociation constant (Kd) (M) |
|---|---|---|---|---|
 Wild type | 915.278 | 41 | − 15.4 | 4.8E–12 |
 V843F | 720.354 | 23 | − 11.1 | 7.2E–09 |
 A889V | 1019.921 | 31 | − 15.4 | 4.7E–12 |
 V843F + A889V | 968.296 | 28 | − 15.5 | 4.2E–12 |