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Table 2 Enriched pathways and the involved target genes of the studied miRNAs in each pathway

From: Epigenetic effects toward new insights as potential therapeutic target in B-thalassemia

Pathway Target genes of the studied microRNAs involved in that pathway
Predicted Validated
Insulin signaling pathway AKT2, BRAF, KRAS, SOS1, PDPK1, CALM1, ERS2, INSR, MAPK1, MAPK3, MAPK8, MAPK9, MAPK10, NRAS, PIK3R1, PIK3R2, PIK3R3, PRKAA1, PRKAA2, PRKAB2, RPS6KB1 AKT3, KRAS, FOXO1
MAPK signaling pathway AKT2, BRAF, KRAS, SOS1, EGFR, MAPK1, MAPK3, MAPK8, MAPK9, MAPK10, MAP2K4, NRAS, TGFBR1, TGFBR2 AKT3, KRAS, RPS6KA3
Neurotrophin signaling pathway PDPK1, ABL1, AKT2, BRAF, KRAS, SOS1, CALM1, BCL2, FOXO3, PIK3R1, MAPK1, MAPK3, MAPK8, MAPK9, MAPK10, NRAS, PIK3R1, PIK3R2, PIK3R3, AKT3, KRAS, BCL2, FOXO3, RPS6KA3
Chronic myeloid leukemia ABL1, AKT2, E2F1, E2F2, E2F3, BRAF, KRAS, MDM2, SMAD4, SOS1, CCND1, CDK6, MAPK1, MAPK3, NRAS, PIK3R1, PIK3R2, PIK3R3, RUNX1, STAT5B, TGFBR1, TGFBR2 AKT3, KRAS, CCND1
Ras signaling pathway ABL1, AKT2, KRAS, SOS1, CALM1, IGF1R, EGFR, INSR, MAPK1, MAPK3, MAPK8, MAPK9, MAPK10, NRAS, PIK3R1, PIK3R2, PIK3R3 AKT3, KRAS
FOXO signaling pathway PDPK1, AKT2, BRAF, KRAS, SOS1, BC2L11, GABARAPL1, MDM2, SMAD2, SMAD3, SMAD4, CCND1, CCND2, EGFR, FOXO1, FOXO3, IGF1R, IRS2, INSR, IL7R, MAPK1, MAPK3, MAPK8, MAPK9, MAPK10, NRAS, PIK3R1, PIK3R2, PIK3R3, PRKAA1, PRKAA2, PRKAB2, SGK1, TGFBR1, TGFBR2 AKT3, KRAS, CCND1, CCND2
GnRH signaling pathway KRAS, SOS1, CALM1, EGFR, MAPK1, MAPK3, MAPK8, MAPK9, MAPK10, MAP2K4, NRAS KRAS