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Table 3 Genes, NATs, lncRNAs, and corresponding mice. List of mouse strains showing probable inadvertent partial/complete disruption of overlapping sequence of NATs on the antisense strand along with intended target genes

From: Inadvertent nucleotide sequence alterations during mutagenesis: highlighting the vulnerabilities in mouse transgenic technology

Genes and gene ID

Function

NAT/lncRNA

Example of mouse strains

References

IL-1α (16175)

Regulatory role in immune response by promoting inflammation.

AS IL-1α

C57BL/6 J-Il1aem1(Luc-eGFP)Smoc mice

[14]

B6N(Cg)-Il1atm1b(EUCOMM)Wtsi/J (stock No.027517)

[46]

HoxD-3 (15434)

Transcription factor that plays a regulatory role in morphogenesis

Hoxd3os1

Hoxd3−/− mice

[12]

Hoxa3−/−;hoxd3−/− mice

[13]

Igf2r (16004)

Receptor for insulin-like growth factor 2 and mannose 6-phosphate. Involved in intracellular lysosomal enzyme trafficking.

Airn

Igf2r mutant mice

[33]

Dlx-1 (13390)

Homeobox transcription factor involved in craniofacial patterning.

Dlx-1as

STOCK Dlx1/Dlx2tm1.1Rth/J (stock No. 025612)

[45]

Msx1 (17701)

Transcriptional repressor that plays a major regulatory role during early embryogenesis.

Msx1as

Msx1flox mice (stock No. 025204)

[17]